Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Pregnancy and Childbirth

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 5 · 71.4%Moderate 1 · 14.3%High 0 · 0%

Early amniocentesis vs transabdominal chorionic villus sampling

All known pregnancy loss (including termination of pregnancy) · prenatal diagnosis

Early amniocentesis showed no clear difference in all known pregnancy loss (including termination of pregnancy) compared with transabdominal chorionic villus sampling (low certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 1.15 [0.86, 1.54]
4 studies · 5491 participants
Low

Early amniocentesis vs transabdominal chorionic villus sampling

Miscarriage · prenatal diagnosis

Early amniocentesis probably leads to higher spontaneous miscarriage compared with transabdominal chorionic villus sampling (moderate certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 1.73 [1.15, 2.6]
4 studies · 5491 participants
Moderate

Early amniocentesis vs transabdominal chorionic villus sampling

Sampling failure · prenatal diagnosis

Early amniocentesis showed no clear difference in sampling failure compared with transabdominal chorionic villus sampling (low certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 0.58 [0.24, 1.38]
4 studies · 5566 participants
Low

Early amniocentesis vs transabdominal chorionic villus sampling

Laboratory failure · prenatal diagnosis

Early amniocentesis showed no clear difference in laboratory failure compared with transabdominal chorionic villus sampling (low certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 0.74 [0.34, 1.63]
4 studies · 5566 participants
Low

Early amniocentesis vs transabdominal chorionic villus sampling

Known false negative after birth · prenatal diagnosis

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 555 participants
Low

Early amniocentesis vs transabdominal chorionic villus sampling

Delivery before 33 weeks · prenatal diagnosis

Early amniocentesis showed no clear difference in delivery before 33 weeks compared with transabdominal chorionic villus sampling (low certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 0.5 [0.09, 2.73]
1 study · 1121 participants
Low

Early amniocentesis vs transabdominal chorionic villus sampling

Anomalies (all recorded) · prenatal diagnosis

It is very uncertain whether early amniocentesis changes anomalies (all recorded) compared with transabdominal chorionic villus sampling (very low certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 1.14 [0.57, 2.3]
4 studies · 5305 participants
Very low