Cochrane · systematic review · CD003252
Amniocentesis and chorionic villus sampling for prenatal diagnosis
Alfirevic, Z, Navaratnam, K, Mujezinovic, F · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
36
current version
GRADE rated
26
No studies
10
Included studies
NR
No studies 10 · 27.8%Ungraded 0 · 0%Very low 3 · 8.3%Low 10 · 27.8%Moderate 8 · 22.2%High 5 · 13.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Second trimester amniocentesis compared to control for prenatal diagnosis
Population: prenatal diagnosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All known pregnancy loss (including termination of pregnancy) Second trimester amniocentesis vs control | RR 1.41 [0.99, 2] | 1 study · 4606 participants | Moderate Downgraded: imprecision |
Spontaneous miscarriage Second trimester amniocentesis vs control | RR 1.6 [1.02, 2.52] | 1 study · 4606 participants | High |
Sampling failure Second trimester amniocentesis vs control | no estimate extracted | NR | No studies |
Laboratory failure Second trimester amniocentesis vs control | RR 27.02 [1.61, 454.31] | 1 study · 4606 participants | High |
Known false negative after birth Second trimester amniocentesis vs control | no estimate extracted | NR | No studies |
Delivery before 33 weeks Second trimester amniocentesis vs control | no estimate extracted | NR | No studies |
Anomalies (all recorded) Second trimester amniocentesis vs control | RR 0.93 [0.62, 1.39] | 1 study · 4507 participants | Moderate Downgraded: imprecision |
Early compared to second trimester amniocentesis for prenatal diagnosis
Population: prenatal diagnosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All known pregnancy loss (including termination of pregnancy) Early vs second trimester amniocentesis | RR 1.29 [1.03, 1.61] | 1 study · 4334 participants | High |
Spontaneous miscarriage Early vs second trimester amniocentesis | RR 1.41 [1, 1.98] | 1 study · 4334 participants | Moderate Downgraded: risk of bias, imprecision |
Sampling failure Early vs second trimester amniocentesis | RR 4.53 [0.53, 38.56] | 1 study · 629 participants | Moderate Downgraded: risk of bias, imprecision |
Laboratory failure Early vs second trimester amniocentesis | RR 9.76 [3.49, 27.26] | 1 study · 4368 participants | High |
Known false negative after birth Early vs second trimester amniocentesis | RR 3 [0.12, 73.67] | 1 study · 4368 participants | Moderate Downgraded: risk of bias, imprecision |
Known false negative after birth ‐ Incorrect sex determination Early vs second trimester amniocentesis | RR 5 [0.24, 104.18] | 1 study · 4368 participants | Moderate Downgraded: risk of bias, imprecision |
Delivery before 33 weeks Early vs second trimester amniocentesis | no estimate extracted | NR | No studies |
Anomalies (all recorded) Early vs second trimester amniocentesis | RR 1.73 [1.26, 2.38] | 1 study · 4334 participants | High |
Transabdominal chorionic villus sampling compared to second trimester amniocentesis for prenatal diagnosis
Population: prenatal diagnosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All known pregnancy loss (including termination of pregnancy) Transabdominal chorionic villus sampling vs second trimester amniocentesis | RR 0.9 [0.66, 1.23] | 1 study · 2234 participants | Low |
Spontaneous miscarriage Transabdominal chorionic villus sampling vs second trimester amniocentesis | RR 0.77 [0.49, 1.21] | 1 study · 2069 participants | Low |
Sampling failure Transabdominal chorionic villus sampling vs second trimester amniocentesis | no estimate extracted | NR | No studies |
Laboratory failure Transabdominal chorionic villus sampling vs second trimester amniocentesis | no estimate extracted | NR | No studies |
Known false negative after birth Transabdominal chorionic villus sampling vs second trimester amniocentesis | no estimate extracted | NR | No studies |
Delivery before 33 weeks Transabdominal chorionic villus sampling vs second trimester amniocentesis | no estimate extracted | NR | No studies |
Perinatal deaths (stillbirths and neonatal deaths in the first week of life) Transabdominal chorionic villus sampling vs second trimester amniocentesis | RR 1.18 [0.4, 3.51] | 1 study · 2069 participants | Low |
Transcervical compared to transabdominal chorionic villus sampling for prenatal diagnosis
Population: prenatal diagnosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All known pregnancy loss (including termination of pregnancy) Transcervical vs transabdominal chorionic villus sampling | RR 1.16 [0.81, 1.65] | 5 studies · 7978 participants | Very low |
Spontaneous miscarriage Transcervical vs transabdominal chorionic villus sampling | RR 1.68 [0.79, 3.58] | 4 studies · 3384 participants | Very low |
Sampling failure Transcervical vs transabdominal chorionic villus sampling | RR 1.79 [1.13, 2.82] | 4 studies · 5231 participants | Moderate Downgraded: imprecision, inconsistency |
Laboratory failure Transcervical vs transabdominal chorionic villus sampling | RR 2.23 [0.69, 7.22] | 1 study · 1194 participants | Low |
Known false negative after birth Transcervical vs transabdominal chorionic villus sampling | no estimate extracted | NR | No studies |
Delivery before 33 weeks Transcervical vs transabdominal chorionic villus sampling | no estimate extracted | NR | No studies |
Anomalies (all recorded) Transcervical vs transabdominal chorionic villus sampling | RR 0.68 [0.41, 1.12] | 2 studies · 3622 participants | Low |
Early amniocentesis compared to transabdominal chorionic villus sampling for prenatal diagnosis
Population: prenatal diagnosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All known pregnancy loss (including termination of pregnancy) Early amniocentesis vs transabdominal chorionic villus sampling | RR 1.15 [0.86, 1.54] | 4 studies · 5491 participants | Low |
Spontaneous miscarriage Early amniocentesis vs transabdominal chorionic villus sampling | RR 1.73 [1.15, 2.6] | 4 studies · 5491 participants | Moderate |
Sampling failure Early amniocentesis vs transabdominal chorionic villus sampling | RR 0.58 [0.24, 1.38] | 4 studies · 5566 participants | Low |
Laboratory failure Early amniocentesis vs transabdominal chorionic villus sampling | RR 0.74 [0.34, 1.63] | 4 studies · 5566 participants | Low |
Known false negative after birth Early amniocentesis vs transabdominal chorionic villus sampling | no estimate extracted | 1 study · 555 participants | Low Downgraded: imprecision, inconsistency |
Delivery before 33 weeks Early amniocentesis vs transabdominal chorionic villus sampling | RR 0.5 [0.09, 2.73] | 1 study · 1121 participants | Low Downgraded: imprecision, inconsistency |
Anomalies (all recorded) Early amniocentesis vs transabdominal chorionic villus sampling | RR 1.14 [0.57, 2.3] | 4 studies · 5305 participants | Very low |