Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

89 questions · 93 findings · 22 reviews

No studies found 11 · 11.8%GRADE not reported 0 · 0%Very low 40 · 43%Low 27 · 29%Moderate 13 · 14%High 2 · 2.2%

Very early treatment vs expectant management

Severe intraventricular hemorrhage in infants who received neuroimaging · preterm infants

Very early treatment showed no clear difference in severe Intraventricular hemorrhage (grades III and IV) compared with expectant management (moderate certainty).

1 finding from 1 review

Very early treatment vs expectant management

Neurodevelopmental outcomes (moderate/severe cognitive delay at 18 to 24 months) · preterm infants

Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe cognitive delay at 18… compared with expectant management (low certainty).

1 finding from 1 review

Very early treatment vs expectant management

Neurodevelopmental outcomes (moderate/severe motor delay at 18 to 24 months) · preterm infants

Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe motor delay at 18 to 24… compared with expectant management (low certainty).

1 finding from 1 review

Very early treatment vs expectant management

Neurodevelopmental outcomes (moderate/severe language delay at 18 to 24 months) · preterm infants

Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe language delay at 18 to… compared with expectant management (low certainty).

1 finding from 1 review

Very early treatment vs expectant management

Proportion of infants requiring surgical PDA ligation or transcatheter occlusion · preterm infants

Very early treatment showed no clear difference in proportion of infants requiring surgical PDA ligation or… compared with expectant management (moderate certainty).

1 finding from 1 review

Very early treatment vs expectant management

Proportion of infants receiving any pharmacotherapy for a hemodynamically significant PDA · preterm infants

It is very uncertain whether very early treatment changes proportion of infants receiving any pharmacotherapy for a… compared with expectant management (very low certainty).

1 finding from 1 review

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Functional assessment using a patient reported outcome measure: · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa
2 findings from 1 review

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Active finger range of motion · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa
2 findings from 1 review

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Tendon rupture · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa

It is very uncertain whether early active flexion plus controlled passive exercise regimen changes adverse event (tendon rupture) compared with early controlled passive exercise regimen (very low certainty).

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Recovered · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) may leads to higher global state: recovery (assessed by proportion recovered, as defined… compared with treatment (low certainty).

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Service use: disengagement from services (assessed by proportion disengaged, as defined by the study, at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) probably leads to lower service use: disengagement from services (assessed by proportion… compared with treatment (moderate certainty).

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Service use: admission to psychiatric hospital (assessed by proportion admitted at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) showed no clear difference in service use: admission to psychiatric hospital (assessed by… compared with treatment (low certainty).

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Mental state: 1b.Average end point score on various outcomes‐PANSS (medium‐term) ‐ Medium term ‐ PANSS general psychopathology end point score (low = favourable) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)
1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Death: all‐cause mortality (assessed by proportion deceased at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) showed no clear difference in death: all‐cause mortality (assessed by proportion deceased at end… compared with treatment (low certainty).

1 finding from 1 review