Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

449 questions · 486 findings · 74 reviews

No studies found 34 · 7%GRADE not reported 73 · 15%Very low 127 · 26.1%Low 158 · 32.5%Moderate 69 · 14.2%High 25 · 5.1%

Early loading of mini-screw implant vs Delayed loading of mini-screw implant

Success of the anchorage device · Patients undergoing orthodontic treatment requiring surgical (mini-screw implant) anchorage

Early loading of mini-screw implant showed no clear difference in success of the anchorage device compared with delayed loading of mini-screw implant; GRADE not reported.

1 finding from 1 review

Very early cerebral revascularization vs delayed treatment

Perioperative death and strokes · people with recently symptomatic carotid artery stenosis

It is very uncertain whether very early cerebral revascularization changes stroke and Death < 30 days compared with delayed treatment (very low certainty).

2 findings from 1 review

Early treatment (two-phase) with headgear vs Late treatment (one-phase in adolescence) with headgear

PAR score · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase) with headgear showed no clear difference in PAR score compared with late treatment (one-phase in adolescence) with headgear; GRADE not reported.

1 finding from 1 review

Early treatment (two-phase) with headgear vs Late treatment (one-phase in adolescence) with headgear

Incidence of new incisal trauma · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase) with headgear may leads to lower incidence of new incisal trauma compared with late treatment (one-phase in adolescence) with headgear (low certainty).

1 finding from 1 review

Early treatment (two-phase) with headgear vs Late treatment (one-phase in adolescence) with headgear

Final overjet · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase) with headgear showed no clear difference in final overjet compared with late treatment (one-phase in adolescence) with headgear (low certainty).

2 findings from 1 review

Early treatment (two-phase) with headgear vs Late treatment (one-phase in adolescence) with headgear

Incidence of incisal trauma · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase) with headgear showed no clear difference in incidence of incisal trauma compared with late treatment (one-phase in adolescence) with headgear; GRADE not reported.

1 finding from 1 review

Early treatment (two-phase) with headgear vs Late treatment (one-phase in adolescence) with headgear

Final ANB · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase) with headgear led to lower final ANB compared with late treatment (one-phase in adolescence) with headgear; GRADE not reported.

2 findings from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

All allergic disease ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes all allergic disease ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs cow's milk formula

Food allergy ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes food allergy ‐ childhood (incidence) compared with cow's milk formula ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs cow's milk formula

Cow's milk allergy ‐ infancy (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes cow's milk allergy ‐ infancy (incidence) compared with cow's milk formula ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs cow's milk formula

Cow's milk allergy ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes cow's milk allergy ‐ childhood (incidence) compared with cow's milk formula ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Asthma ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes asthma ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Eczema ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes eczema ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Food allergy ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes food allergy ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Cow's milk allergy ‐ infancy (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes cow's milk allergy ‐ infancy (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Cow's milk allergy ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes cow's milk allergy ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs cow's milk formula

All allergic disease ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes all allergic disease ‐ childhood (incidence) compared with cow's milk formula ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs cow's milk formula

Asthma ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes asthma ‐ childhood (incidence) compared with cow's milk formula ‐ low‐risk infants (very low certainty).

1 finding from 1 review