Findings

What do systematic reviews say?

8 questions · 8 findings · 2 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 1 · 12.5%Very low 6 · 75%Low 1 · 12.5%Moderate 0 · 0%High 0 · 0%

Dexmedetomidine vs control or placebo medications

Adverse effects: 1. Sedation · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 52 participants
Very low

Dexmedetomidine vs traditional sedative agents

Duration of mechanical ventilation · Critically ill patients requiring long‐term sedation during mechanical ventilation

1 finding from 1 review

Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1120 participants
Low

Dexmedetomidine vs traditional sedative agents

Risk of delirium · Critically ill patients requiring long‐term sedation during mechanical ventilation

It is very uncertain whether dexmedetomidine changes risk of delirium compared with traditional sedative agents (very low certainty).

1 finding from 1 review

Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
RR 0.85 [0.63, 1.14]
7 studies · 1624 participants
Very low

Dexmedetomidine vs traditional sedative agents

Risk of coma · Critically ill patients requiring long‐term sedation during mechanical ventilation

It is very uncertain whether dexmedetomidine changes risk of coma compared with traditional sedative agents (very low certainty).

1 finding from 1 review

Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
RR 0.69 [0.55, 0.86]
1 study · 103 participants
Very low

Dexmedetomidine vs traditional sedative agents

Bradycardia · Critically ill patients requiring long‐term sedation during mechanical ventilation

It is very uncertain whether dexmedetomidine changes incidence of bradycardia compared with traditional sedative agents (very low certainty).

1 finding from 1 review

Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
RR 2.11 [1.39, 3.2]
6 studies · 1587 participants
Very low

Dexmedetomidine vs traditional sedative agents

Total duration of weaning defined as study randomization to successful extubation (hours) · Critically ill patients requiring long‐term sedation during mechanical ventilation

1 finding from 1 review

Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 85 participants
GRADE not reported

Dexmedetomidine vs traditional sedative agents

Duration of ICU stay · Critically ill patients requiring long‐term sedation during mechanical ventilation

1 finding from 1 review

Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1223 participants
Very low

Dexmedetomidine vs traditional sedative agents

All‐cause mortality · Critically ill patients requiring long‐term sedation during mechanical ventilation

It is very uncertain whether dexmedetomidine changes mortality compared with traditional sedative agents (very low certainty).

1 finding from 1 review

Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
RR 0.99 [0.79, 1.24]
6 studies · 1584 participants
Very low