Findings

What do systematic reviews say?

3 questions · 5 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 4 · 80%Very low 1 · 20%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Early childhood caries (ECC) vs Caries-free controls

Relative abundance of Veillonella spp. · Young children with early childhood caries and caries-free controls

Veillonella spp. is more abundant in children with early childhood caries than in caries-free children (mean difference 2.22, 95% CI 0.54 to 3.90); very low certainty.

3 findings from 1 review · compare the 2 reviews

Meta-Analysis Using NGS Data: The Veillonella Species in Dental Caries. 2022 All outcomes
Saliva and supragingival biofilm (pooled) · Overall (all sample types)
MD 2.22 [0.54, 3.90]
6 studies · 319 participants
Very low
Meta-Analysis Using NGS Data: The Veillonella Species in Dental Caries. 2022 All outcomes
Saliva · Saliva
MD -1.05 [-7.67, 5.57]
2 studies · 161 participants
GRADE not reported
Meta-Analysis Using NGS Data: The Veillonella Species in Dental Caries. 2022 All outcomes
Supragingival biofilm/plaque · Supragingival biofilm/plaque
MD 3.11 [0.67, 5.55]
4 studies · 158 participants
GRADE not reported

Dental caries (ECC/severe ECC) as exposure/grouping vs Caries-free controls

Relative abundance of S. mutans in saliva · Individuals assessed for dental caries, predominantly children with early childhood caries (ECC) or severe ECC (age about 1 to 4 years)

A few small studies report Streptococcus mutans relative abundance in caries versus caries-free children without pooling; the evidence is ungraded and not meta-analyzed.

1 finding from 1 review

A systematic review of Streptococcus Mutans and Veillonellae species interactions in dental caries progression:… 2025 All outcomes
Community and clinical pediatric dental settings (USA, Hong Kong, Indonesia); saliva or dental plaque microbial sampling
Reported in 2 studies without pooling: Agnello 2017 median S. mutans relative abundance 0.73% (0.02-22.9) in caries vs 0.15% (0.006-10.4) in controls; Chalmers 2015 Streptococcus 35.63+/-17.04 (caries) vs 32.11+/-18.91…
1 study · 50 participants
GRADE not reported

Dental caries (ECC/severe ECC) as exposure/grouping vs Caries-free controls

Relative abundance of Veillonella spp. · Individuals assessed for dental caries, predominantly children with early childhood caries (ECC) or severe ECC (age about 1 to 4 years)

Evidence on whether Veillonella spp. relative abundance is higher or lower in children with dental caries than caries-free controls is inconsistent across 7 small observational studies; no pooled estimate was produced and the evidence is ungraded.

1 finding from 1 review

A systematic review of Streptococcus Mutans and Veillonellae species interactions in dental caries progression:… 2025 All outcomes
Community and clinical pediatric dental settings (USA, Hong Kong, Indonesia); saliva or dental plaque microbial sampling
No meta-analysis was performed (too few studies). Across 7 studies the direction was inconsistent: Veillonella spp. relative abundance was higher in caries than in caries-free subjects in some studies (Setiawan 2020:…
3 studies · 146 participants
GRADE not reported