Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

415 questions · 442 findings · 58 reviews

No studies found 70 · 15.8%GRADE not reported 19 · 4.3%Very low 99 · 22.4%Low 137 · 31%Moderate 86 · 19.5%High 31 · 7%

Systemic corticosteroids vs placebo

Pain (dichotomous) Pain improved (definitions varied)c · people with radicular low back pain (not due to spinal stenosis)

Systemic corticosteroids showed no clear difference in pain (dichotomous) Pain improved (definitions varied)c compared with placebo (moderate certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo

Function (dichotomous) Function improved (definitions varied)f · people with radicular low back pain (not due to spinal stenosis)

Systemic corticosteroids probably leads to higher function (dichotomous) Function improved (definitions varied)f compared with placebo (moderate certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo

Mortality or serious adverse events requiring hospital admission · people with radicular low back pain (not due to spinal stenosis)

It is very uncertain whether systemic corticosteroids changes participants who experienced a serious adverse event Adverse event… compared with placebo (very low certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo

Participants with hyperglycemia "Transient hyperglycemia" or blood sugar increase ≥ 50 mg/dL · people with radicular low back pain (not due to spinal stenosis)

Systemic corticosteroids showed no clear difference in participants with hyperglycemia "Transient hyperglycemia" or blood… compared with placebo (low certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo

Dyspnea · adults with cancer‐related breathlessness (dyspnoea)
2 findings from 1 review