Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 10 findings · 4 reviews

No studies found 2 · 20%GRADE not reported 0 · 0%Very low 3 · 30%Low 0 · 0%Moderate 1 · 10%High 4 · 40%

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Serious adverse events · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids probably leads to higher serious adverse events compared with moderate‐dose or no corticosteroids (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo compared

Serious adverse events (dichotomous data) ‐ suspected or probable pneumonia · critically ill patients

Corticosteroids showed no clear difference in serious adverse events (dichotomous data) ‐ suspected or probable… compared with placebo compared (high certainty).

1 finding from 1 review