Findings

What do systematic reviews say?

7 questions · 7 findings · 3 reviews

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No studies found 2 · 28.6%GRADE not reported 1 · 14.3%Very low 0 · 0%Low 2 · 28.6%Moderate 2 · 28.6%High 0 · 0%

Corticosteroids vs placebo or usual care

Hospital mortality · children and adults with sepsis

Corticosteroids probably leads to lower hospital mortality compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
RR 0.9 [0.82, 0.99]
26 studies · 8183 participants
Moderate

Corticosteroids vs placebo or usual care

Long‐term mortalityc · children and adults with sepsis

Corticosteroids showed no clear difference in long‐term mortalityc compared with placebo or usual care (low certainty).

1 finding from 1 review

Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
RR 0.97 [0.91, 1.03]
7 studies · 6236 participants
Low

Corticosteroids vs placebo or usual care

28‐Day all‐cause mortalitya · children and adults with sepsis

Corticosteroids probably leads to lower 28‐Day all‐cause mortalitya compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
RR 0.91 [0.84, 0.99]
50 studies · 11233 participants
Moderate

Betamethasone vs usual care

Severe maternal morbidity and mortality index · women undergoing planned elective caesarean section at 37 weeks' gestation and beyond for singleton pregnancy

1 finding from 1 review

Antenatal corticosteroids prior to planned caesarean at term for improving neonatal outcomes 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Strategies to increase use of antenatal corticosteroids vs usual care

Maternal death · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids showed no clear difference in maternal mortality (at population level) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 1.11 [0.64, 1.92]
1 study · 99742 participants
Low

Strategies to increase use of antenatal corticosteroids vs usual care

Offspring mortality or severe neonatal morbidity · women at risk of preterm birth

The review found no eligible studies for this question.

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Strategies to increase use of antenatal corticosteroids vs usual care

Offspring mortality, early neurodevelopmental morbidity or late neurodevelopmental morbidity · women at risk of preterm birth

The review found no eligible studies for this question.

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found