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What do systematic reviews say?

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Evidence found and GRADE certainty

47 questions · 48 findings · 7 reviews

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No studies found 16 · 33.3%GRADE not reported 0 · 0%Very low 20 · 41.7%Low 8 · 16.7%Moderate 2 · 4.2%High 2 · 4.2%

Continuous local anaesthetic wound infusion vs placebo

Any serious postoperative adverse event (until hospital discharge) · adults undergoing elective midline laparotomy for colorectal resection

Continuous local anaesthetic wound infusion showed no clear difference in any serious postoperative adverse event (until hospital discharge) compared with placebo (low certainty).

1 finding from 1 review

Continuous platinum infusion vs bolus platinum infusion

Hearing loss · children with cancer treated with platinum‐based therapy

Continuous platinum infusion showed no clear difference in hearing loss (asymptomatic and symptomatic disease according to… compared with bolus platinum infusion (low certainty).

1 finding from 1 review

Continuous platinum infusion vs bolus platinum infusion

Adverse effects: toxic death (no definition provided) · children with cancer treated with platinum‐based therapy

Continuous platinum infusion showed no clear difference in adverse effects: toxic death (no definition provided) compared with bolus platinum infusion (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Mortality before hospital discharge · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in all‐cause mortality (from admission to discharge) compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Hospital readmission · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in readmission to hospital following discharge compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review