What do systematic reviews say?

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Higher BMI (continuous / per-unit increment) vs Lower BMI (continuous reference / per 1 kg/m2 decrement)

Pooling studies that used BMI as a continuous variable showed no significant association between per-unit BMI and childhood dental caries (OR 1.01, 95% CI 0.99 to 1.03; I2=3.5%); ungraded.

• Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomes

  Dental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Continuous BMI, direct pooling (studies reporting BMI as a continuous variable)
  OR 1.01 [0.99, 1.03]
  4 studies
  GRADE not reported
• Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomes

  Dental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Non-linear dose-response (restricted cubic splines)
  Fig. 5: significant non-linear (restricted cubic spline) dose-response between BMI and childhood dental caries; relative risk rises at higher BMI (curve reaches ~2.4-2.9 at BMI 30-35) and is also elevated among…
  Studies not reported
  GRADE not reported
• Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomes

  Dental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Linear dose-response (GLST, per 1 kg/m2 BMI increment)
  OR 1.01 [1.00, 1.03]
  16 studies
  GRADE not reported

Continuous chest compression alone vs interrupted chest compression plus artificial ventilation

Continuous chest compression alone leads to higher survival to hospital discharge compared with interrupted chest compression plus artificial ventilation (high certainty).

• Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non‐asphyxial… 2017 · Cochrane Headline outcomes only
  RR 1.21 [1.01, 1.46]
  3 studies · 3031 participants
  High

Continuous chest compression alone vs interrupted chest compression plus artificial ventilation

Continuous chest compression alone showed no clear difference in survival to hospital admission compared with interrupted chest compression plus artificial ventilation (moderate certainty).

• Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non‐asphyxial… 2017 · Cochrane Headline outcomes only
  RR 1.18 [0.94, 1.48]
  1 study · 520 participants
  Moderate

Continuous chest compression alone vs interrupted chest compression plus artificial ventilation

• Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non‐asphyxial… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Continuous chest compression alone vs interrupted chest compression plus artificial ventilation

Continuous chest compression alone showed no clear difference in neurological outcomes at hospital discharge Measured as 'good' or… compared with interrupted chest compression plus artificial ventilation (moderate certainty).

• Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non‐asphyxial… 2017 · Cochrane Headline outcomes only
  RR 1.25 [0.94, 1.66]
  1 study · 1286 participants
  Moderate

Continuous chest compression alone vs interrupted chest compression plus artificial ventilation

• Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non‐asphyxial… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Continuous chest compression alone vs interrupted chest compression plus artificial ventilation

• Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non‐asphyxial… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Continuous chest compression alone vs interrupted chest compression plus artificial ventilation

• Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non‐asphyxial… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Continuous phenobarbital vs placebo or no treatment

Continuous phenobarbital showed no clear difference in recurrent seizure at 18 months compared with placebo or no treatment (moderate certainty).

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  RR 0.77 [0.56, 1.05]
  2 studies · 264 participants
  Moderate

Continuous phenobarbital vs placebo or no treatment

Continuous phenobarbital probably leads to lower recurrent seizure at 24 months compared with placebo or no treatment (moderate certainty).

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  RR 0.69 [0.53, 0.89]
  3 studies · 533 participants
  Moderate

Continuous phenobarbital vs placebo or no treatment

The review found no eligible studies for this question.

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Continuous phenobarbital vs placebo or no treatment

The review found no eligible studies for this question.

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Continuous phenobarbital vs placebo or no treatment

It is very uncertain whether continuous phenobarbital changes recurrent seizure at 60 months or greater compared with placebo or no treatment (very low certainty).

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  RR 1.5 [0.61, 3.69]
  1 study · 60 participants
  Very low

Continuous phenobarbital vs intermittent rectal or oral diazepam

The review found no eligible studies for this question.

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Continuous phenobarbital vs intermittent rectal or oral diazepam

Continuous phenobarbital showed no clear difference in recurrent seizure at 12 months compared with intermittent rectal or oral diazepam (low certainty).

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  RR 1.48 [0.75, 2.94]
  1 study · 145 participants
  Low

Continuous phenobarbital vs intermittent rectal or oral diazepam

It is very uncertain whether continuous phenobarbital changes recurrent seizure at 18 months compared with intermittent rectal or oral diazepam (very low certainty).

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  RR 1.25 [0.36, 4.38]
  1 study · 100 participants
  Very low

Continuous phenobarbital vs intermittent rectal or oral diazepam

The review found no eligible studies for this question.

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Continuous phenobarbital vs intermittent rectal or oral diazepam

The review found no eligible studies for this question.

• Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found