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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews · Colorectal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 0 · 0%Moderate 3 · 42.9%High 2 · 28.6%

Combination chemotherapy vs single‐agent chemotherapy

Overall survival (3 years) · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery

It is very uncertain whether combination chemotherapy changes overall survival (3 years) compared with single‐agent chemotherapy (very low certainty).

1 finding from 1 review

Combination chemotherapy vs single‐agent chemotherapy

Disease-free survival · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery

It is very uncertain whether combination chemotherapy changes disease‐free survival (3 years) compared with single‐agent chemotherapy (very low certainty).

1 finding from 1 review

Combination chemotherapy vs single‐agent chemotherapy

Complete response rate after preoperative chemoradiation (ypCR) · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery

Combination chemotherapy leads to higher complete response rate after preoperative chemoradiation (ypCR) compared with single‐agent chemotherapy (high certainty).

1 finding from 1 review

Combination chemotherapy vs single‐agent chemotherapy

Toxicity ‐ early adverse events G3/4 · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery

Combination chemotherapy probably leads to higher toxicity ‐ early adverse events G3/4 compared with single‐agent chemotherapy (moderate certainty).

1 finding from 1 review

Combination chemotherapy vs single‐agent chemotherapy

Metastases intra‐abdominal · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery

Combination chemotherapy showed no clear difference in metastases intra‐abdominal compared with single‐agent chemotherapy (moderate certainty).

1 finding from 1 review

Combination chemotherapy vs single‐agent chemotherapy

Radiotherapy compliance · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery

Combination chemotherapy probably leads to lower radiotherapy compliance compared with single‐agent chemotherapy (moderate certainty).

1 finding from 1 review

Combination chemotherapy vs single‐agent chemotherapy

Chemotherapy compliance · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery

Combination chemotherapy leads to lower chemotherapy compliance compared with single‐agent chemotherapy (high certainty).

1 finding from 1 review