Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 1 · 50%Moderate 0 · 0%High 0 · 0%

Combination vs nicotine replacement therapy monotherapy

Overall serious adverse events · people who smoke

Combination showed no clear difference in overall serious adverse events compared with single‐form nicotine replacement therapy (low certainty).

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
RR 4.44 [0.76, 25.85]
5 studies · 2888 participants
Low

Combinations of antipsychotic drugs vs single antipsychotic drugs

Adverse events: Serious event or requiring discontinuation · schizophrenia or related disorders

It is very uncertain whether combinations of antipsychotic drugs changes adverse events: Serious event or requiring discontinuation compared with single antipsychotic drugs (very low certainty).

1 finding from 1 review

Antipsychotic combinations for schizophrenia 2017 · Cochrane Headline outcomes only
RR 1.05 [0.65, 1.69]
30 studies · 2398 participants
Very low