What do systematic reviews say?

3 questions · 6 findings · 1 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 6 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Cleft lip and/or palate (CL/P) vs No cleft lip and/or palate (non-CL/P)

Early childhood caries experience (mean dmft) · Children in the primary dentition with non-syndromic cleft lip and/or palate (CL/P) and comparable children without CL/P

In the combined primary and mixed dentition, there was no evidence of a difference in caries experience between children with and without CL/P (SMD 0.09, 95% CI -0.59-0.76; 5 studies; ungraded).

4 findings from 1 review

Caries in children with and without orofacial clefting: A systematic review and meta-analysis. 2022 All outcomes
Children with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021 · Primary and mixed dentition
SMD 0.09 [-0.59, 0.76]
5 studies · 708 participants
GRADE not reported
Caries in children with and without orofacial clefting: A systematic review and meta-analysis. 2022 All outcomes
Children with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021 · Mixed dentition
SMD 1.74 [0.24, 3.25]
4 studies · 789 participants
GRADE not reported
Caries in children with and without orofacial clefting: A systematic review and meta-analysis. 2022 All outcomes
Children with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021 · Primary dentition
SMD 0.27 [0.06, 0.49]
10 studies · 2366 participants
GRADE not reported

Show 1 more finding

Caries in children with and without orofacial clefting: A systematic review and meta-analysis. 2022 All outcomes
Children with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021 · Overall (all dentition groups)
SMD 0.46 [0.15, 0.77]
16 studies · 3863 participants
GRADE not reported

Cleft lip and/or palate (CL/P) vs No cleft lip and/or palate (non-CL/P)

Care index (CI = f/[d+m+f]) in the primary dentition · Children in the primary dentition with non-syndromic cleft lip and/or palate (CL/P) and comparable children without CL/P

The care index tended to be higher in children without CL/P (2 of 3 studies), suggesting more extraction-based caries management in children with CL/P; not pooled (narrative; ungraded).

1 finding from 1 review

Caries in children with and without orofacial clefting: A systematic review and meta-analysis. 2022 All outcomes
Children with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021
Two out of three studies for which the CI could be calculated (Nagappan 2019; Veiga 2016) showed a higher CI for non-CL/P children demonstrating a higher proportion of extraction-based treatment in CL/P children…
3 studies
GRADE not reported

Cleft lip and/or palate (CL/P) vs No cleft lip and/or palate (non-CL/P)

Restorative index (RI = f/[d+f]) in the primary dentition · Children in the primary dentition with non-syndromic cleft lip and/or palate (CL/P) and comparable children without CL/P

The restorative index tended to be lower in children with CL/P (3 of 5 studies), indicating a lower proportion of restoratively managed carious teeth; not pooled (narrative; ungraded).

1 finding from 1 review

Caries in children with and without orofacial clefting: A systematic review and meta-analysis. 2022 All outcomes
Children with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021
Of the five studies for which the RI could be calculated, three of them (Dahllof 1989; Nagappan 2019; Veiga 2016) showed a lower RI for children with CL/P compared to children with no CL/P demonstrating a lower…
5 studies
GRADE not reported