Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

16 questions · 16 findings · 3 reviews · Headline outcomes only

No studies found 3 · 18.8%GRADE not reported 0 · 0%Very low 4 · 25%Low 3 · 18.8%Moderate 6 · 37.5%High 0 · 0%

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ overall comparison between chlorhexidine and povidone‐iodine (during in‐patient stay) · patients with a central venous catheter

It is very uncertain whether chlorhexidine changes catheter‐related BSI ‐ overall comparison between chlorhexidine and… compared with povidone‐iodine (very low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ subgroup: chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution · patients with a central venous catheter

It is very uncertain whether chlorhexidine changes catheter‐related BSI ‐ subgroup: chlorhexidine in aqueous solution… compared with povidone‐iodine (very low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus povidone‐iodine in aqueous solution · patients with a central venous catheter

It is very uncertain whether chlorhexidine changes catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus… compared with povidone‐iodine (very low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus povidone‐iodine in alcohol · patients with a central venous catheter

Chlorhexidine showed no clear difference in catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus… compared with povidone‐iodine (moderate certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

All‐cause mortality ‐ Chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution Clinical assessment · patients with a central venous catheter

Chlorhexidine showed no clear difference in all‐cause mortality ‐ Chlorhexidine in aqueous solution versus… compared with povidone‐iodine (low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

All‐cause mortality ‐ Chlorhexidine in alcohol versus povidone‐iodine in aqueous solution Clinical assessment · patients with a central venous catheter

Chlorhexidine showed no clear difference in all‐cause mortality ‐ Chlorhexidine in alcohol versus… compared with povidone‐iodine (low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Adverse events (maternal) ‐ skin irritation or allergic skin reaction · women undergoing caesarean section

It is very uncertain whether chlorhexidine gluconate changes adverse events (maternal) ‐ skin irritation or allergic skin reaction compared with povidone iodine (very low certainty).

1 finding from 1 review

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Sepsis without a source · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing showed no clear difference in sepsis without a source compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Catheter‐related blood stream infection · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing showed no clear difference in catheter‐related blood stream infection compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Catheter colonisation · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing probably leads to lower catheter colonisation compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Adverse effects: contact dermatitis · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing probably leads to higher adverse effects: contact dermatitis compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review