Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

383 questions · 397 findings · 37 reviews

No studies found 59 · 14.9%GRADE not reported 11 · 2.8%Very low 70 · 17.6%Low 86 · 21.7%Moderate 110 · 27.7%High 61 · 15.4%

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus lower‐dose radiation showed no clear difference in secondary malignant neoplasms compared with same chemotherapy plus higher‐dose radiation (low certainty).

1 finding from 1 review

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Death · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus lower‐dose radiation showed no clear difference in death compared with same chemotherapy plus higher‐dose radiation (high certainty).

1 finding from 1 review

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Progression/relapse · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus lower‐dose radiation showed no clear difference in progression/relapse compared with same chemotherapy plus higher‐dose radiation (high certainty).

1 finding from 1 review

Chemotherapy plus involved‐field radiation vs same chemotherapy plus extended‐field radiation

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus involved‐field radiation showed no clear difference in secondary malignant neoplasms compared with same chemotherapy plus extended‐field radiation (low certainty).

1 finding from 1 review

Chemotherapy plus involved‐field radiation vs same chemotherapy plus extended‐field radiation

Death · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus involved‐field radiation showed no clear difference in death compared with same chemotherapy plus extended‐field radiation (high certainty).

1 finding from 1 review

Chemotherapy plus involved‐field radiation vs same chemotherapy plus extended‐field radiation

Progression/relapse · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus involved‐field radiation showed no clear difference in progression/relapse compared with same chemotherapy plus extended‐field radiation (high certainty).

1 finding from 1 review

Interferon + chemotherapy vs chemotherapy alone

Adverse event (flu‐like symptoms) · Women with advanced (Stage II‐IV) epithelial ovarian cancer who have undergone surgery

Interferon + chemotherapy showed no clear difference in adverse event (flu‐like symptoms) compared with chemotherapy alone (low certainty).

1 finding from 1 review

Hysterectomy (radical) with neoadjuvant chemotherapy vs chemoradiotherapy alone

Death (all causes) · women with locally advanced cervical cancer

Hysterectomy (radical) with neoadjuvant chemotherapy showed no clear difference in overall survival Median compared with chemoradiotherapy alone (moderate certainty).

1 finding from 1 review