Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Gut

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 20%Low 2 · 40%Moderate 1 · 20%High 1 · 20%

Overall survival · nonmetastatic esophageal cancer

Chemoradiotherapy showed no clear difference in overall survival compared with chemoradiotherapy plus surgery (high certainty).

1 finding from 1 review

Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer 2017 · Cochrane Headline outcomes only
HR 0.99 [0.79, 1.24]
2 studies · 431 participants
High

Freedom from locoregional relapse · nonmetastatic esophageal cancer

Chemoradiotherapy probably leads to lower freedom from locoregional relapse compared with chemoradiotherapy plus surgery (moderate certainty).

1 finding from 1 review

Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer 2017 · Cochrane Headline outcomes only
HR 0.55 [0.39, 0.76]
2 studies · 431 participants
Moderate

Quality of life · nonmetastatic esophageal cancer

1 finding from 1 review

Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 165 participants
Very low

Treatment‐related mortality · nonmetastatic esophageal cancer

Chemoradiotherapy may leads to higher treatment‐related mortality compared with chemoradiotherapy plus surgery (low certainty).

1 finding from 1 review

Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer 2017 · Cochrane Headline outcomes only
RR 5.11 [1.74, 15.02]
2 studies · 431 participants
Low

Use of salvage procedures for dysphagia · nonmetastatic esophageal cancer

Chemoradiotherapy may leads to lower use of salvage procedures for dysphagia compared with chemoradiotherapy plus surgery (low certainty).

1 finding from 1 review

Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer 2017 · Cochrane Headline outcomes only
RR 0.52 [0.36, 0.75]
1 study · 259 participants
Low