Findings

What do systematic reviews say?

14 questions · 14 findings · 2 reviews · Headline outcomes only

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No studies found 6 · 42.9%GRADE not reported 0 · 0%Very low 7 · 50%Low 1 · 7.1%Moderate 0 · 0%High 0 · 0%

Ceftriaxone vs penicillin G

Serological cure assessed by decrease in the CSF VDRL titre · people with neurosyphilis

1 finding from 1 review

Antibiotic therapy for adults with neurosyphilis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 36 participants
Very low

Ceftriaxone vs penicillin G

Clinical cure assessed by RPR decrease · people with neurosyphilis

1 finding from 1 review

Antibiotic therapy for adults with neurosyphilis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 36 participants
Very low

Ceftriaxone vs penicillin G

Adverse events Any untoward medical occurrence regarding medications · people with neurosyphilis

1 finding from 1 review

Antibiotic therapy for adults with neurosyphilis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Very low

Ceftriaxone vs penicillin G

Recurrence of neurosyphilis · people with neurosyphilis

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for adults with neurosyphilis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ceftriaxone vs penicillin G

Time to recovery · people with neurosyphilis

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for adults with neurosyphilis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ceftriaxone vs penicillin G

Quality of life · people with neurosyphilis

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for adults with neurosyphilis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ceftriaxone vs penicillin G

Treatment withdrawal · people with neurosyphilis

It is very uncertain whether ceftriaxone changes withdrawals compared with penicillin G (very low certainty).

1 finding from 1 review

Antibiotic therapy for adults with neurosyphilis 2019 · Cochrane Headline outcomes only
RR 2 [0.42, 9.48]
1 study · 36 participants
Very low

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with infective endocarditis due to penicillin‐susceptible Streptococci

The review found no eligible studies for this question.

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Cure · people with infective endocarditis due to penicillin‐susceptible Streptococci

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) showed no clear difference in cure compared with beta‐lactam (ceftriaxone) (low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 0.69 [0.44, 1.1]
1 study · 67 participants
Low

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Adverse events · people with infective endocarditis due to penicillin‐susceptible Streptococci

It is very uncertain whether beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) changes adverse events compared with beta‐lactam (ceftriaxone) (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 0.58 [0.15, 2.24]
1 study · 67 participants
Very low

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Congestive heart failure · people with infective endocarditis due to penicillin‐susceptible Streptococci

The review found no eligible studies for this question.

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Septic embolism · people with infective endocarditis due to penicillin‐susceptible Streptococci

The review found no eligible studies for this question.

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Need for cardiac surgical interventions · people with infective endocarditis due to penicillin‐susceptible Streptococci

It is very uncertain whether beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) changes need for cardiac surgical interventions compared with beta‐lactam (ceftriaxone) (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 1.75 [0.65, 4.67]
1 study · 67 participants
Very low

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Uncontrolled infection · people with infective endocarditis due to penicillin‐susceptible Streptococci

It is very uncertain whether beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) changes uncontrolled infection compared with beta‐lactam (ceftriaxone) (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 0.97 [0.06, 14.88]
1 study · 67 participants
Very low