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Evidence found and GRADE certainty

10 questions · 13 findings · 4 reviews

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No studies found 0 · 0%GRADE not reported 5 · 38.5%Very low 0 · 0%Low 3 · 23.1%Moderate 5 · 38.5%High 0 · 0%

Calcium phosphate vs control

Immediate (24 h) resin-dentin bond strength (MPa) · permanent human teeth with artificial caries-affected dentin

Calcium phosphate minus Control was -21.209 MPa (95% CI -25.954 to -16.463) at 24 h.

2 findings from 1 review

Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) vs Calcium-based agent

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Etch-and-Rinse adhesive + chemical ACAD protocol network, Calcium Phosphate vs Calcium showed no significant difference in 24 h bond strength (MD 0.596, 95% CI -7.289 to 8.482; Low certainty).

2 findings from 1 review

CPP-ACP vs Pre-treatment (baseline, same group)

Quantitative light-induced fluorescence (QLF), fluorescence loss · Patients (mainly children) with white spot lesions (WSL)

Compared with baseline, CPP-ACP significantly improved white spot lesions on QLF (SMD -0.43, 95% CI -0.79 to -0.07; ungraded).

1 finding from 1 review

CPP-ACP vs Placebo paste without CPP-ACP (fluoride toothpaste control)

Quantitative light-induced fluorescence (QLF), fluorescence loss · Patients (mainly children) with white spot lesions (WSL)

CPP-ACP toothpaste did not differ significantly from placebo paste (fluoride control) for white spot lesion remineralization on QLF (MD 0.08, 95% CI -0.91 to 1.08; ungraded).

1 finding from 1 review

ACP light-cure adhesive vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control

Enamel demineralization (DIAGNOdent score) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)

A single triple-blinded RCT found the ACP-containing adhesive reduced enamel demineralization versus a conventional adhesive over 6 months (ungraded).

1 finding from 1 review

Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Calcium Phosphate vs Fluorine showed no significant difference in 24 h bond strength (MD 2.140, 95% CI -1.506 to 5.787; Moderate certainty).

2 findings from 1 review

Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) vs No biomimetic remineralization (control)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Calcium Phosphate vs Control showed no significant difference in 24 h bond strength (MD 1.539, 95% CI -1.738 to 4.817; Moderate certainty).

1 finding from 1 review

Orthodontic adhesives containing nano-amorphous calcium phosphate (n-ACP) particles/nanoparticles vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control

Enamel remineralization extent · Human enamel specimens around orthodontic brackets (in vitro)

In vitro, n-ACP-containing orthodontic adhesives showed significant enamel remineralization versus control in both studies, but evidence is weak (only 2 studies; ungraded).

1 finding from 1 review

Experimental orthodontic adhesive containing amorphous fluorinated calcium phosphate nanoparticles (n-AFCP) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control

Enamel remineralization extent and color change · Human enamel specimens around orthodontic brackets (in vitro)

In vitro, an n-AFCP-containing orthodontic primer showed significant enamel remineralization and less color change versus control in a single study (ungraded).

1 finding from 1 review