Orthodontic adhesives containing nano-amorphous calcium phosphate (n-ACP) particles/nanoparticles vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control: Enamel remineralization extent
- Population
- Human enamel specimens around orthodontic brackets (in vitro)
- Intervention
- Orthodontic adhesives containing nano-amorphous calcium phosphate (n-ACP) particles/nanoparticles
- Comparison
- Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control
- Outcome
- Enamel remineralization extent
In vitro, n-ACP-containing orthodontic adhesives showed significant enamel remineralization versus control in both studies, but evidence is weak (only 2 studies; ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Orthodontic adhesives containing nano-amorphous calcium phosphate (n-ACP) particles/nanoparticles vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control Enamel remineralization extent · Human enamel specimens around orthodontic brackets (in vitro) · pH cycling / biofilm challenge 14 to 28 days, In vitro (laboratory), Overall In vitro, n-ACP-containing orthodontic adhesives showed significant enamel remineralization versus control in both studies, but evidence is weak (only 2 studies; ungraded). Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic… (2024) All outcomes | Studies using orthodontic adhesives containing n-ACP showed statistically significant remineralization compared with control orthodontic adhesives [15, 33]. | 2 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic brackets: a systematic review… 2024 All outcomes | 2005 to 2024 (search coverage; exact search date not reported) | 25 | Low / Low |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Antibacterial and remineralizing orthodontic adhesive containing quaternary ammonium resin monomer and amorphous calcium phosphate… · 2018 · included by 1 of these review
- Novel multifunctional dental cement to prevent enamel demineralization near orthodontic brackets. · 2017 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.