Findings

What do systematic reviews say?

22 questions · 29 findings · 7 reviews

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No studies found 0 · 0%GRADE not reported 19 · 65.5%Very low 0 · 0%Low 5 · 17.2%Moderate 5 · 17.2%High 0 · 0%

Bleaching gel with added remineralising agent (fluoride, calcium, or CPP-ACP) vs Bleaching alone (no remineralising agent)

Whitening (bleaching) efficacy · Demineralised / white-spot-lesion enamel (in vitro specimens)

Low-quality in vitro evidence indicates that adding fluoride or other remineralising agents does not impair the whitening/bleaching effect (ungraded).

1 finding from 1 review

Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. 2020 All outcomes
In vitro laboratory studies
Low-quality in vitro data indicated that the presence of fluoride or any other remineralising agent did not impair the whitening effect.
3 studies
GRADE not reported

Bleaching gel with added remineralising agent (fluoride, calcium, or CPP-ACP) vs Bleaching alone (no remineralising agent)

Enamel mineral loss / remineralisation · Demineralised / white-spot-lesion enamel (in vitro specimens)

Low-quality in vitro evidence indicates that adding fluoride, calcium or CPP-ACP to bleaching agents can reduce enamel mineral loss (ungraded).

1 finding from 1 review

Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. 2020 All outcomes
In vitro laboratory studies
Inconclusive: F/Ca/CPP-ACP additives reduced mineral loss on SOUND enamel (refs 8,10,16) but not verified for artificial caries lesions (ref 35)
4 studies
GRADE not reported