Findings

What do systematic reviews say?

5 questions · 5 findings · 2 reviews · Airways

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 100%Moderate 0 · 0%High 0 · 0%

Budesonide/formoterol (BDF) vs placebo

Adverse events—'serious'—320/94 Duration of 10 months3 · COPD

Budesonide/formoterol (BDF) showed no clear difference in adverse events—'serious'—320/94 Duration of 10 months3 compared with placebo (low certainty).

1 finding from 1 review

Combined corticosteroid and long‐acting beta₂‐agonist in one inhaler versus placebo for chronic obstructive pulmonary… 2013 · Cochrane Headline outcomes only
OR 1.17 [0.95, 1.45]
2476 participants
Low

Budesonide/formoterol (BDF) vs placebo

Adverse events—'serious'—160/94 Duration of nine months 3 · COPD

Budesonide/formoterol (BDF) showed no clear difference in adverse events—'serious'—160/94 Duration of nine months 3 compared with placebo (low certainty).

1 finding from 1 review

Combined corticosteroid and long‐acting beta₂‐agonist in one inhaler versus placebo for chronic obstructive pulmonary… 2013 · Cochrane Headline outcomes only
OR 1.2 [0.89, 1.63]
1556 participants
Low

Budesonide/formoterol (BDF) vs placebo

Adverse event—any—320/94 Duration of nine months 3 · COPD

Budesonide/formoterol (BDF) may leads to higher adverse event—any—320/94 Duration of nine months 3 compared with placebo (low certainty).

1 finding from 1 review

Combined corticosteroid and long‐acting beta₂‐agonist in one inhaler versus placebo for chronic obstructive pulmonary… 2013 · Cochrane Headline outcomes only
OR 1.42 [1.16, 1.74]
1552 participants
Low

Budesonide/formoterol (BDF) vs placebo

Adverse event—any—160/94 Duration of nine months 3 · COPD

Budesonide/formoterol (BDF) may leads to higher adverse event—any—160/94 Duration of nine months 3 compared with placebo (low certainty).

1 finding from 1 review

Combined corticosteroid and long‐acting beta₂‐agonist in one inhaler versus placebo for chronic obstructive pulmonary… 2013 · Cochrane Headline outcomes only
OR 1.32 [1.08, 1.61]
1556 participants
Low

Effects of different delivery devices on growth in children with persistent asthma: Easyhaler‐budesonide vs Turbuhaler‐budesonide

Change in height · children up to 18 years of age with persistent asthma

Effects of different delivery devices on growth in children with… may leads to higher change in height (cm) over a period of time compared with turbuhaler‐budesonide (low certainty).

1 finding from 1 review

Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth 2019 · Cochrane Headline outcomes only
MD 0.37 [0.12, 0.62]
1 study · 229 participants
Low