Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

23 questions · 27 findings · 3 reviews · Heart

No studies found 6 · 22.2%GRADE not reported 0 · 0%Very low 6 · 22.2%Low 10 · 37%Moderate 4 · 14.8%High 1 · 3.7%

Beta‐blockers vs placebo or no treatment

Heart failure hospitalisation (RR) · patients with chronic heart failure with preserved ejection fraction

It is very uncertain whether beta‐blockers changes heart failure hospitalisation (RR) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Beta‐blockers vs placebo or no intervention

MACE · patients with suspected or diagnosed myocardial infarction

It is very uncertain whether beta‐blockers changes MACE (major adverse cardiovascular event) at maximum compared with placebo or no intervention (very low certainty).

2 findings from 1 review

Beta‐blockers vs placebo or no intervention

Angina · patients with suspected or diagnosed myocardial infarction

It is very uncertain whether beta‐blockers changes angina at maximum compared with placebo or no intervention (very low certainty).

2 findings from 1 review

Beta‐blockers vs placebo or no intervention

Cardiovascular mortality · patients with suspected or diagnosed myocardial infarction

Beta‐blockers probably leads to lower cardiovascular mortality at maximum compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

Beta‐blockers vs placebo or no intervention

Myocardial infarction · patients with suspected or diagnosed myocardial infarction

Beta‐blockers showed no clear difference in myocardial infarction at maximum compared with placebo or no intervention (low certainty).

2 findings from 1 review

Beta‐blockers vs placebo, no treatment or surveillance only

Clinically important non‐fatal end point as defined byShores 1994(aortic dissection, aortic regurgitation, congestive heart failure, or cardiovascular surgery) · people with confirmed diagnosis of Marfan syndrome

Beta‐blockers showed no clear difference in clinically important non‐fatal end point as defined byShores… compared with placebo, no treatment or surveillance only (low certainty).

1 finding from 1 review