What do systematic reviews say?

Psychological therapies vs other antidepressants

All psychological therapies showed no clear difference in short‐term response compared with other antidepressants (low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 0.96 [0.67, 1.37]
  3 studies · 128 participants
  Low

Psychological therapies vs benzodiazepines

It is very uncertain whether all psychological therapies changes short‐term response compared with benzodiazepines (very low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 1.58 [0.7, 3.58]
  2 studies · 69 participants
  Very low

Psychological therapies vs SSRI

It is very uncertain whether all psychological therapies changes short‐term response compared with SSRI (very low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 0.97 [0.51, 1.86]
  5 studies · 277 participants
  Very low

Psychological therapies vs antidepressants alone or antidepressants and benzodiazepines

All psychological therapies showed no clear difference in short‐term response compared with antidepressants alone or antidepressants and benzodiazepines (low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 0.95 [0.76, 1.18]
  12 studies · 800 participants
  Low

Psychological therapies vs tricyclic antidepressants (TCAs)

All psychological therapies showed no clear difference in short‐term response compared with tricyclic antidepressants (low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 0.75 [0.51, 1.1]
  4 studies · 270 participants
  Low

Cognitive behaviour therapy vs psychodynamic psychotherapy

It is very uncertain whether cognitive behaviour therapy changes short‐term response ( compared with psychodynamic psychotherapy (very low certainty).

• Psychological therapies for panic disorder with or without agoraphobia in adults: a network meta‐analysis 2016 · Cochrane Headline outcomes only
  OR 1.05 [0.28, 4]
  1 study · 54 participants
  Very low

Intervention not reported

• Psychological therapies for panic disorder with or without agoraphobia in adults: a network meta‐analysis 2016 · Cochrane Headline outcomes only
  no estimate extracted
  37 studies · 2240 participants
  Low

Cognitive behaviour therapy vs no treatment

It is very uncertain whether cognitive behaviour therapy changes short‐term response ( compared with no treatment (very low certainty).

• Psychological therapies for panic disorder with or without agoraphobia in adults: a network meta‐analysis 2016 · Cochrane Headline outcomes only
  OR 7.14 [1.25, 50]
  2 studies · 357 participants
  Very low

Cognitive behaviour therapy vs supportive psychotherapy

It is very uncertain whether cognitive behaviour therapy changes short‐term response ( compared with supportive psychotherapy (very low certainty).

• Psychological therapies for panic disorder with or without agoraphobia in adults: a network meta‐analysis 2016 · Cochrane Headline outcomes only
  OR 1.12 [0.4, 3.26]
  3 studies · 176 participants
  Very low