Findings

What do systematic reviews say?

6 questions · 12 findings · 1 reviews · Periodontology

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No studies found 1 · 8.3%GRADE not reported 8 · 66.7%Very low 3 · 25%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft)

Change in radiographic bone defect filling (RBF) (%) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

Autologous platelet concentrates (APC) + open flap debridement (OFD)… led to higher change in radiographic bone defect filling (RBF) (%) compared with OFD + BG (open flap debridement + bone graft); GRADE not reported.

3 findings from 1 review

Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
9 to 12 months
MD 9.99 [6.44, 13.55]
6 studies · 282 participants
GRADE not reported
Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
3 to 6 months
MD 4.76 [1.27, 8.25]
6 studies · 162 participants
GRADE not reported
Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
All follow-ups
MD 8.10 [5.26, 10.94]
11 studies · 420 participants
Very low

Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft)

Attachment change · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD)… changes change in clinical attachment level (CAL) (mm) compared with OFD + BG (open flap debridement + bone graft) (very low certainty).

3 findings from 1 review

Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
All follow-ups
MD 0.72 [0.43, 1.00]
17 studies · 569 participants
Very low
Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
3 to 6 months
MD 0.47 [0.11, 0.84]
11 studies · 272 participants
GRADE not reported
Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
9 to 12 months · Split-mouth studies only
MD 0.84 [0.62, 1.06]
6 studies · 192 participants
GRADE not reported

Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft)

Change in probing pocket depth (PPD) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD)… changes change in probing depth (PD) (mm) compared with OFD + BG (open flap debridement + bone graft) (very low certainty).

3 findings from 1 review

Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
All follow-ups
MD 0.54 [0.33, 0.75]
17 studies · 569 participants
Very low
Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
3 to 6 months
MD 0.62 [0.30, 0.94]
11 studies · 272 participants
GRADE not reported
Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
9 to 12 months
MD 0.50 [0.31, 0.69]
10 studies · 381 participants
GRADE not reported

Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft)

Pocket closure (complete pocket closure) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

1 finding from 1 review

Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
No complete pocket closure was reported (outcome addressed across included studies; no usable comparative estimate).
Studies not reported
GRADE not reported

Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft)

Tooth survival · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

1 finding from 1 review

Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
All studies in all groups reported a survival rate of 100% for the treated teeth (no comparative estimate; not GRADE-rated).
17 studies
GRADE not reported

Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft)

Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

The review found no eligible studies for this question.

1 finding from 1 review

Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
No quantitative analysis regarding patients' quality of life was possible (no data).
0 studies
No studies found