Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft): Change in probing pocket depth (PPD)
- Population
- Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
- Intervention
- Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG)
- Comparison
- OFD + BG (open flap debridement + bone graft)
- Outcome
- Change in probing pocket depth (PPD)
It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD)… changes change in probing depth (PD) (mm) compared with OFD + BG (open flap debridement + bone graft) (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft) Change in probing depth (PD) (mm) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender · All follow-ups It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD)… changes change in probing depth (PD) (mm) compared with OFD + BG (open flap debridement + bone graft) (very low certainty). Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane All outcomes | MD 0.54 [0.33, 0.75] | 17 studies · 569 participants | Very low |
Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft) Change in probing depth (PD) (mm) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender · 3 to 6 months Autologous platelet concentrates (APC) + open flap debridement (OFD)… led to higher change in probing depth (PD) (mm) compared with OFD + BG (open flap debridement + bone graft); GRADE not reported. Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane All outcomes | MD 0.62 [0.30, 0.94] | 11 studies · 272 participants | GRADE not reported |
Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft) Change in probing depth (PD) (mm) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender · 9 to 12 months Autologous platelet concentrates (APC) + open flap debridement (OFD)… led to higher change in probing depth (PD) (mm) compared with OFD + BG (open flap debridement + bone graft); GRADE not reported. Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane All outcomes | MD 0.50 [0.31, 0.69] | 10 studies · 381 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes | 27 February 2018 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.