Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 2 · 50%High 0 · 0%

Anticonvulsant vs placebo

Dropout · patients with cocaine dependence

Any anticonvulsant showed no clear difference in dropout Number of participants who did not complete the treatment compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsants for cocaine dependence 2015 · Cochrane Headline outcomes only
RR 0.95 [0.86, 1.05]
17 studies · 1695 participants
Moderate

Number of participants using cocaine during the treatment (as days/week by urine tests or self report) Number of participants that reported the use of cocaine during the treatment · patients with cocaine dependence

Any anticonvulsant showed no clear difference in use of cocaine (self reported or objective) Number of participants… compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsants for cocaine dependence 2015 · Cochrane Headline outcomes only
RR 0.92 [0.84, 1.02]
9 studies · 867 participants
Moderate

Anticonvulsant vs placebo

Participants with at least some Side Effects · patients with cocaine dependence

Any anticonvulsant may leads to higher side effect Number of participants reporting at least 1 side effect… compared with placebo (low certainty).

1 finding from 1 review

Anticonvulsants for cocaine dependence 2015 · Cochrane Headline outcomes only
RR 1.39 [1.01, 1.9]
8 studies · 775 participants
Low

Anticonvulsant vs placebo

Craving · patients with cocaine dependence

1 finding from 1 review

Anticonvulsants for cocaine dependence 2015 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 428 participants
Low