Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 1 · 14.3%Very low 3 · 42.9%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%

Antipsychotic dose increase vs antipsychotic dose continuation

Global state: clinically relevant response: · non response in schizophrenia

Antipsychotic dose increase showed no clear difference in global state: clinically relevant response: compared with antipsychotic dose continuation (low certainty).

1 finding from 1 review

Increasing antipsychotic dose for non response in schizophrenia 2018 · Cochrane Headline outcomes only
RR 1.09 [0.86, 1.4]
9 studies · 533 participants
Low

Antipsychotic dose increase vs antipsychotic dose continuation

Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · non response in schizophrenia

It is very uncertain whether antipsychotic dose increase changes leaving the study early: tolerability ‐ leaving early due to adverse… compared with antipsychotic dose continuation (very low certainty).

1 finding from 1 review

Increasing antipsychotic dose for non response in schizophrenia 2018 · Cochrane Headline outcomes only
RR 1.63 [0.52, 5.07]
7 studies · 496 participants
Very low

Antipsychotic dose increase vs antipsychotic dose continuation

Acceptability of treatment ‐ leaving the study early · non response in schizophrenia

Antipsychotic dose increase showed no clear difference in leaving the study early: acceptability ‐ leaving early due to any… compared with antipsychotic dose continuation (low certainty).

1 finding from 1 review

Increasing antipsychotic dose for non response in schizophrenia 2018 · Cochrane Headline outcomes only
RR 1.3 [0.89, 1.9]
5 studies · 353 participants
Low

Antipsychotic dose increase vs antipsychotic dose continuation

Clinical response: mean score/change in mental state: mean PANSS total score (high = poor) · non response in schizophrenia

1 finding from 1 review

Increasing antipsychotic dose for non response in schizophrenia 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 258 participants
Very low

Antipsychotic dose increase vs antipsychotic dose continuation

Risk for at least one adverse event per patient · non response in schizophrenia

It is very uncertain whether antipsychotic dose increase changes adverse effects ‐ at least one adverse effect compared with antipsychotic dose continuation (very low certainty).

1 finding from 1 review

Increasing antipsychotic dose for non response in schizophrenia 2018 · Cochrane Headline outcomes only
RR 0.91 [0.55, 1.5]
2 studies · 191 participants
Very low

Antipsychotic dose increase vs antipsychotic dose continuation

Service use: time in hospital · non response in schizophrenia

1 finding from 1 review

Increasing antipsychotic dose for non response in schizophrenia 2018 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Antipsychotic dose increase vs antipsychotic dose continuation

Proportion of participants with at least 50% improvement in their quality of life ‐ not reported · non response in schizophrenia

1 finding from 1 review

Increasing antipsychotic dose for non response in schizophrenia 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Low