Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

191 questions · 199 findings · 21 reviews · Headline outcomes only

No studies found 46 · 23.1%GRADE not reported 3 · 1.5%Very low 60 · 30.2%Low 63 · 31.7%Moderate 25 · 12.6%High 2 · 1%

Antidepressants vs placebo: all studies

Response to antidepressive treatment · people with co‐occurring depression and alcohol dependence

It is very uncertain whether antidepressants changes response to antidepressive treatment compared with placebo: all studies (very low certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

> 50% reduction in depressive symptoms · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants showed no clear difference in severity of depression dichotomous measures ‐ >50% reduction in… compared with placebo according to any definition (low certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

Severity of depression dichotomous measures ‐ "very much" or "much" improved on the Clinical Global Impression Scale · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants may leads to higher severity of depression dichotomous measures ‐ "very much" or "much"… compared with placebo according to any definition (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Severity of depression dichotomous measures ‐ "very much" or "much" improved on the Clinical Global Impression Scale · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants may leads to higher severity of depression dichotomous measures ‐ "very much" or "much"… compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

> 50% reduction in depressive symptoms · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants showed no clear difference in severity of depression dichotomous measures ‐ >50% reduction in… compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Depression response (acute phase, 5 ≤ 12 weeks) · women of any age, with PND up to 12 months

Antidepressants showed no clear difference in depression response (acute, 5 ≤ 12 weeks) compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs treatment

Depression remission · women of any age, with PND up to 12 months

It is very uncertain whether antidepressants changes depression remission (early phase, < 5 weeks) compared with treatment (very low certainty).

1 finding from 1 review

Antidepressants vs placebo

Depression remission · women of any age, with PND up to 12 months

Antidepressants showed no clear difference in depression remission (acute, 5 ≤ 12 weeks) compared with placebo (low certainty).

1 finding from 1 review