Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

191 questions · 199 findings · 21 reviews · Headline outcomes only

No studies found 46 · 23.1%GRADE not reported 3 · 1.5%Very low 60 · 30.2%Low 63 · 31.7%Moderate 25 · 12.6%High 2 · 1%

Antidepressants vs placebo: all studies

Response to antidepressive treatment · people with co‐occurring depression and alcohol dependence

It is very uncertain whether antidepressants changes response to antidepressive treatment compared with placebo: all studies (very low certainty).

1 finding from 1 review

Antidepressants vs placebo: all studies

Consumption of alcohol: abstinent participants (number) · people with co‐occurring depression and alcohol dependence

Antidepressants probably leads to higher consumption of alcohol: abstinent participants (number) compared with placebo: all studies (moderate certainty).

1 finding from 1 review

Antidepressants vs placebo: all studies

Tolerability of treatment: withdrawal for medical reasons · people with co‐occurring depression and alcohol dependence

Antidepressants showed no clear difference in tolerability of treatment: withdrawal for medical reasons compared with placebo: all studies (low certainty).

1 finding from 1 review