Findings

What do systematic reviews say?

232 questions · 246 findings · 18 reviews · Common Mental Disorders

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No studies found 83 · 33.7%GRADE not reported 2 · 0.8%Very low 64 · 26%Low 59 · 24%Moderate 31 · 12.6%High 7 · 2.8%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- Antidepressant vs placebo · Improvement in depression at 6‐12 weeks: HAM‐D score (continuous; standardized mean difference)
  Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 357 participants
  Low
Direct match · question page
- Antidepressant vs placebo · Improvement in depression: HAM‐D score at 6‐12 weeks (dichotomized)
  Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
  RR 1.1 [0.89, 1.35]
  5 studies · 434 participants
  Low
Direct match · question page
- Antidepressant vs placebo · Change in depression severity from baseline
  Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
Direct match · question page
- Antidepressant vs placebo · Improvement in depression at 6‐12 weeks: CGI‐I (score of 1 or 2)
  Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
  RR 1.28 [0.93, 1.77]
  4 studies · 346 participants
  Low
Direct match · question page
- Antidepressant vs placebo · Adverse effects during antidepressant treatment period (0‐12 weeks)
  Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
  RR 0.88 [0.64, 1.21]
  2 studies · 167 participants
  Very low

Antidepressants vs antidepressants

Depression remission · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs antidepressants

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs placebo

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant changes clinical response of depression compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 8.4 [0.5, 142.27]
1 study · 27 participants
Very low

Antidepressants vs antipsychotics

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant changes clinical response of depression compared with antipsychotic (very low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 2.09 [0.64, 6.82]
1 study · 36 participants
Very low

Antidepressants vs antipsychotics

Depression remission · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs antipsychotics

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs placebo

Depression remission · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs placebo

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs placebo

Improvement in depression at 6‐12 weeks: HAM‐D score (continuous) · adults living with HIV and depression

1 finding from 1 review

Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 357 participants
Low

Antidepressants vs placebo

Improvement in depression at 6‐12 weeks: HAM‐D score (dichotomized) · adults living with HIV and depression

Antidepressant showed no clear difference in improvement in depression: HAM‐D score at 6‐12 weeks (dichotomized) compared with placebo (low certainty).

1 finding from 1 review

Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
RR 1.1 [0.89, 1.35]
5 studies · 434 participants
Low

Antidepressants vs placebo

Improvement in depression at 6‐12 weeks: CGI‐I (score of 1 or 2) · adults living with HIV and depression

Antidepressant showed no clear difference in improvement in depression at 6‐12 weeks: CGI‐I (score of 1 or 2) compared with placebo (low certainty).

1 finding from 1 review

Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
RR 1.28 [0.93, 1.77]
4 studies · 346 participants
Low

Antidepressants vs placebo

Adverse effects during antidepressant treatment period (0‐12 weeks) · adults living with HIV and depression

It is very uncertain whether antidepressant changes adverse effects during antidepressant treatment period (0‐12 weeks) compared with placebo (very low certainty).

1 finding from 1 review

Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
RR 0.88 [0.64, 1.21]
2 studies · 167 participants
Very low

Antidepressant plus antipsychotic vs placebo plus antidepressant

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes clinical response of depression compared with placebo plus antidepressant (very low certainty).

2 findings from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.42 [1.11, 1.8]
4 studies · 245 participants
Very low
Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.7 [1.19, 2.43]
3 studies · 157 participants
Very low

Antidepressant plus antipsychotic vs placebo plus antidepressant

Depression remission · adults with psychotic depression

The review found no eligible studies for this question.

2 findings from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo plus antidepressant

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

2 findings from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants plus benzodiazepines vs antidepressants alone

Depression severity ‐ mean EPDS score (early phase, < 5 weeks) · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 598 participants
Moderate

Antidepressants plus benzodiazepines vs antidepressants alone

Depression severity (acute phase, 5 ≤ 12 weeks) · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 347 participants
Low

Antidepressants plus benzodiazepines vs antidepressants alone

Depression severity: continuous phase (> 12 weeks) · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Augmentation of current antidepressant (SSRI/SNRI) with mirtazapine (30 mg/d) vs augmentation of current antidepressant (various) with placebo

Depressive symptoms · treatment‐resistant depression in adults

1 finding from 1 review

Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 431 participants
High

Augmentation of current antidepressant (SSRI) with busiprone (20 mg/d to 60 mg/d) vs placebo plus antidepressant

Depressive symptoms · treatment‐resistant depression in adults

1 finding from 1 review

Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 102 participants
Low