evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

334 questions · 349 findings · 35 reviews · Headline outcomes only

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 93 · 26.6%GRADE not reported 6 · 1.7%Very low 95 · 27.2%Low 94 · 26.9%Moderate 46 · 13.2%High 15 · 4.3%

Antidepressants vs placebo

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant changes clinical response of depression compared with placebo (very low certainty).

1 finding from 1 review

Antidepressants vs placebo

Improvement in depression at 6‐12 weeks: HAM‐D score (dichotomized) · adults living with HIV and depression

Antidepressant showed no clear difference in improvement in depression: HAM‐D score at 6‐12 weeks (dichotomized) compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Improvement in depression at 6‐12 weeks: CGI‐I (score of 1 or 2) · adults living with HIV and depression

Antidepressant showed no clear difference in improvement in depression at 6‐12 weeks: CGI‐I (score of 1 or 2) compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Adverse effects during antidepressant treatment period (0‐12 weeks) · adults living with HIV and depression

It is very uncertain whether antidepressant changes adverse effects during antidepressant treatment period (0‐12 weeks) compared with placebo (very low certainty).

1 finding from 1 review

Antidepressant plus antipsychotic vs placebo plus antidepressant

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes clinical response of depression compared with placebo plus antidepressant (very low certainty).

2 findings from 1 review

Antidepressant plus antipsychotic vs placebo plus antidepressant

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

2 findings from 1 review

Antidepressants vs placebo: all studies

Response to antidepressive treatment · people with co‐occurring depression and alcohol dependence

It is very uncertain whether antidepressants changes response to antidepressive treatment compared with placebo: all studies (very low certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

> 50% reduction in depressive symptoms · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants showed no clear difference in severity of depression dichotomous measures ‐ >50% reduction in… compared with placebo according to any definition (low certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

Severity of depression dichotomous measures ‐ "very much" or "much" improved on the Clinical Global Impression Scale · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants may leads to higher severity of depression dichotomous measures ‐ "very much" or "much"… compared with placebo according to any definition (low certainty).

1 finding from 1 review