Findings

What do systematic reviews say?

152 questions · 159 findings · 14 reviews · Common Mental Disorders

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No studies found 46 · 28.9%GRADE not reported 2 · 1.3%Very low 45 · 28.3%Low 47 · 29.6%Moderate 19 · 11.9%High 0 · 0%

Antidepressants vs placebo

Outcomes (2‐6 months post‐treatment) · adults with panic disorder

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs placebo

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

Antidepressants may leads to lower failure to respond compared with placebo (low certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.72 [0.66, 0.79]
30 studies · 6500 participants
Low

Antidepressants vs placebo

Leaving the study early · adults with panic disorder

Antidepressants probably leads to lower total number of dropouts compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.88 [0.81, 0.97]
38 studies · 7850 participants
Moderate

Antidepressants vs placebo

Failure to remit at endpoint · adults with panic disorder

Antidepressants probably leads to lower failure to remit compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.83 [0.78, 0.88]
24 studies · 6164 participants
Moderate

Antidepressants vs placebo

panic symptoms · adults with panic disorder

2 findings from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 3699 participants
Low
Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 2010 participants
Low

Antidepressants vs placebo

Withdrawals due to adverse events · adults with panic disorder

Antidepressants probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 1.49 [1.25, 1.78]
33 studies · 7688 participants
Moderate

Antidepressants vs benzodiazepines

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

Antidepressants showed no clear difference in failure to respond compared with benzodiazepines (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.99 [0.67, 1.47]
2 studies · 215 participants
Low

Antidepressants vs benzodiazepines

Leaving the study early · adults with panic disorder

It is very uncertain whether antidepressants changes total number of dropouts compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.64 [1.03, 2.63]
7 studies · 1449 participants
Very low

Antidepressants vs benzodiazepines

Failure to remit at endpoint · adults with panic disorder

Antidepressants probably leads to higher failure to remit compared with benzodiazepines (moderate certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.18 [1.01, 1.37]
3 studies · 1002 participants
Moderate

Antidepressants vs benzodiazepines

panic symptoms · adults with panic disorder

2 findings from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1144 participants
Very low
Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Antidepressants vs benzodiazepines

Withdrawals due to adverse events · adults with panic disorder

Antidepressants may leads to higher number of dropouts due to adverse effects compared with benzodiazepines (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.72 [1.03, 2.87]
3 studies · 1002 participants
Low

Antidepressants vs placebo

Gambling symptom severity · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 225 participants
Very low

Antidepressants vs placebo

Gambling expenditure · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 144 participants
Low

Antidepressants vs placebo

Gambling frequency ‐ not measured · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Antidepressants vs opioid antagonists

Gambling symptom severity · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 25 participants
Very low

Antidepressants vs opioid antagonists

Gambling expenditure ‐ not measured · treatment of disordered and problem gambling

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs opioid antagonists

Gambling frequency ‐ not measured · treatment of disordered and problem gambling

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs opioid antagonists

Time spent gambling ‐ not measured · treatment of disordered and problem gambling

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs opioid antagonists

Depressive symptoms · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 62 participants
Very low

Antidepressants vs opioid antagonists

Anxiety · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 62 participants
Very low