Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

236 questions · 244 findings · 29 reviews · Headline outcomes only

No studies found 49 · 20.1%GRADE not reported 5 · 2%Very low 71 · 29.1%Low 77 · 31.6%Moderate 34 · 13.9%High 8 · 3.3%

Antidepressants vs placebo: all studies

Response to antidepressive treatment · people with co‐occurring depression and alcohol dependence

It is very uncertain whether antidepressants changes response to antidepressive treatment compared with placebo: all studies (very low certainty).

1 finding from 1 review

Antidepressants vs placebo: all studies

Consumption of alcohol: abstinent participants (number) · people with co‐occurring depression and alcohol dependence

Antidepressants probably leads to higher consumption of alcohol: abstinent participants (number) compared with placebo: all studies (moderate certainty).

1 finding from 1 review

Antidepressants vs placebo: all studies

Tolerability of treatment: withdrawal for medical reasons · people with co‐occurring depression and alcohol dependence

Antidepressants showed no clear difference in tolerability of treatment: withdrawal for medical reasons compared with placebo: all studies (low certainty).

1 finding from 1 review