Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

249 questions · 257 findings · 31 reviews

No studies found 52 · 20.2%GRADE not reported 5 · 1.9%Very low 81 · 31.5%Low 77 · 30%Moderate 34 · 13.2%High 8 · 3.1%

SSRI antidepressants vs tricyclic antidepressants (TCAs)

Drop‐out Objective · Adults with mental disorders in low‐ and middle‐income countries

It is very uncertain whether SSRI antidepressants changes drop‐outs (12 weeks) compared with TCA (very low certainty).

1 finding from 1 review

Tricyclic antidepressants vs placebo

Clinical global impression (response rate) ‐ desipramine · Children and adolescents with ADHD

Tricyclic antidepressants (TCAs) may leads to higher clinical global impression (response rate) ‐ desipramine compared with placebo (low certainty).

1 finding from 1 review

Tricyclic antidepressants vs placebo

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether tricyclic antidepressants changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).

1 finding from 1 review