Findings

What do systematic reviews say?

349 questions · 364 findings · 37 reviews

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No studies found 96 · 26.4%GRADE not reported 8 · 2.2%Very low 105 · 28.8%Low 94 · 25.8%Moderate 46 · 12.6%High 15 · 4.1%

'Other' antidepressants vs placebo

Quality of sleep · adults with insomnia

1 finding from 1 review

Antidepressants for insomnia in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 370 participants
Moderate

'Other' antidepressants vs placebo

Adverse events · adults with insomnia

1 finding from 1 review

Antidepressants for insomnia in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 217 participants
Low

'Other' antidepressants vs placebo

Sleep efficiency · adults with insomnia

1 finding from 1 review

Antidepressants for insomnia in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 169 participants
Low

Tricyclic antidepressants vs control

Pain < 1 week VAS scale 0 to 100 mm · patients with pain management in rheumatoid arthritis

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Tricyclic antidepressants vs control

Pain 1 to 6 weeks Any pain measurement scale · patients with pain management in rheumatoid arthritis

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 482 participants
Very low

Tricyclic antidepressants vs control

Pain > 6 weeks Any pain measurement scale · patients with pain management in rheumatoid arthritis

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 368 participants
Very low

Tricyclic antidepressants vs control

Functional Status Health Assessment Questionnaire (HAQ) scale 0 to 3 · patients with pain management in rheumatoid arthritis

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Low

Tricyclic antidepressants vs control

Withdrawals due to adverse events · patients with pain management in rheumatoid arthritis

It is very uncertain whether tricyclic antidepressant changes number of Withdrawals due to Adverse Events patient interview compared with control (very low certainty).

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
RR 0.98 [0.59, 1.64]
6 studies · 455 participants
Very low

Tricyclic antidepressants vs control

Total number of adverse events patient interview · patients with pain management in rheumatoid arthritis

It is very uncertain whether tricyclic antidepressant changes total number of adverse events patient interview compared with control (very low certainty).

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
RR 1.83 [1.01, 3.3]
6 studies · 455 participants
Very low

Antidepressants vs placebo

Irritability · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

1 finding from 1 review

Pharmacological intervention for irritability, aggression, and self‐injury in autism spectrum disorder (ASD) 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 267 participants
Low

Antidepressants vs placebo

Aggression · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological intervention for irritability, aggression, and self‐injury in autism spectrum disorder (ASD) 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs placebo

Adverse effects · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

Antidepressants may leads to higher adverse effects compared with placebo (low certainty).

1 finding from 1 review

Pharmacological intervention for irritability, aggression, and self‐injury in autism spectrum disorder (ASD) 2023 · Cochrane Headline outcomes only
RR 4.16
10 studies · 815 participants
Low

Antidepressants vs placebo

Gambling symptom severity · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 225 participants
Very low

Antidepressants vs placebo

Gambling expenditure · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 144 participants
Low

Antidepressants vs placebo

Gambling frequency ‐ not measured · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Antidepressants vs opioid antagonists

Gambling symptom severity · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 25 participants
Very low

Antidepressants vs opioid antagonists

Gambling expenditure ‐ not measured · treatment of disordered and problem gambling

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs opioid antagonists

Gambling frequency ‐ not measured · treatment of disordered and problem gambling

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs opioid antagonists

Time spent gambling ‐ not measured · treatment of disordered and problem gambling

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs opioid antagonists

Anxiety · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 62 participants
Very low