What do systematic reviews say?

Antidepressants vs antidepressants

The review found no eligible studies for this question.

• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressants vs antipsychotics

The review found no eligible studies for this question.

• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressants vs placebo

The review found no eligible studies for this question.

• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressant plus antipsychotic vs placebo plus antidepressant

The review found no eligible studies for this question.

• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressants vs placebo

• Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 87 participants
  Very low

Antidepressant plus antipsychotic vs placebo

The review found no eligible studies for this question.

• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressant plus antipsychotic vs placebo/no adjunctive treatment + antipsychotics

The review found no eligible studies for this question.

• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressants vs placebo

• Adjuvant therapy with antidepressants for the management of inflammatory bowel disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 70 participants
  Low

Antidepressants vs placebo

Antidepressant probably leads to higher quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0… compared with placebo (moderate certainty).

• Antidepressants for hip and knee osteoarthritis 2022 · Cochrane Headline outcomes only
  MD 0.04 [0.01, 0.07]
  3 studies · 815 participants
  Moderate

Augmentation of current antidepressant (SSRI) with busiprone (20 mg/d to 60 mg/d) vs placebo plus antidepressant

The review found no eligible studies for this question.

• Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Augmentation of current antidepressant (fluoxetine 20 mg/d) with mianserin (60 mg/d) vs placebo plus antidepressant

The review found no eligible studies for this question.

• Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Augmentation of current antidepressant (SSRI) with ziprasidone (40 mg/d to 160 mg/d) vs augmentation of current antidepressant (SSRI) with placebo or continue on SSRI monotherapy

The review found no eligible studies for this question.

• Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Augmentation of current antidepressant (various) with cariprazine (1 mg/d to 4.5 mg/d) vs augmentation of current antidepressant (various) with placebo

The review found no eligible studies for this question.

• Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Tricylic antidepressant vs placebo

• Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 30 participants
  Very low

Augmentation of current antidepressant (fluoxetine 20 mg/d to 60 mg/d) with olanzapine (5 mg/d to 20 mg/d) vs augmentation of current antidepressant (fluoxetine 20 mg/d to 60 mg/d) with placebo

The review found no eligible studies for this question.

• Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Augmentation of current antidepressant (SSRI/SNRI) with mirtazapine (30 mg/d) vs augmentation of current antidepressant (various) with placebo

• Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 447 participants
  High

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 146 participants
  Very low

Augmentation of current antidepressant (various) with quetiapine (150 mg/d to 300 mg/d) vs augmentation of current antidepressant (various) with placebo

• Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 884 participants
  Moderate

Antidepressants vs a combination of medications

The review found no eligible studies for this question.

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Exercise therapy plus antidepressants vs antidepressants alone

The review found no eligible studies for this question.

• Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found