What do systematic reviews say?

Anticonvulsant vs placebo

Anticonvulsants showed no clear difference in dropouts compared with placebo (moderate certainty).

• Anticonvulsants for alcohol dependence 2014 · Cochrane Headline outcomes only
  RR 0.94 [0.74, 1.19]
  16 studies · 1675 participants
  Moderate

Anticonvulsant vs placebo

Anticonvulsants showed no clear difference in continuous abstinence compared with placebo (moderate certainty).

• Anticonvulsants for alcohol dependence 2014 · Cochrane Headline outcomes only
  RR 1.21 [0.97, 1.52]
  634 participants
  Moderate

Anticonvulsant vs placebo

• Anticonvulsants for alcohol dependence 2014 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 1126 participants
  Moderate

Anticonvulsant vs placebo

• Anticonvulsants for alcohol dependence 2014 · Cochrane Headline outcomes only
  no estimate extracted
  12 studies · 1129 participants
  Moderate

Anticonvulsant vs placebo

Anticonvulsants showed no clear difference in adverse events—withdrawn for medical reasons compared with placebo (moderate certainty).

• Anticonvulsants for alcohol dependence 2014 · Cochrane Headline outcomes only
  RR 1.22 [0.58, 2.56]
  12 studies · 1410 participants
  Moderate

Anticonvulsants and mood stabilisers vs placebo

It is very uncertain whether anticonvulsants and mood stabilisers changes participants abstinent at end of treatment compared with placebo (very low certainty).

• Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
  RR 1.14 [0.64, 2.04]
  2 studies · 48 participants
  Very low

Anticonvulsants and mood stabilisers vs placebo

It is very uncertain whether anticonvulsants and mood stabilisers changes participants withdrawn due to adverse effects compared with placebo (very low certainty).

• Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
  RR 3.67 [0.41, 32.69]
  2 studies · 116 participants
  Very low

Anticonvulsants and mood stabilisers vs placebo

Anticonvulsants and mood stabilisers may leads to lower completion of scheduled treatment compared with placebo (low certainty).

• Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
  RR 0.66 [0.47, 0.92]
  3 studies · 141 participants
  Low