What do systematic reviews say?

Antibiotics vs no treatment or placebo on top of topical antiseptics

• Systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 204 participants
  Very low

Antibiotics vs no treatment/placebo

The review found no eligible studies for this question.

• Systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antibiotics vs no treatment/placebo

The review found no eligible studies for this question.

• Systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antibiotics vs no treatment/placebo

• Systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 33 participants
  Very low

Antibiotics vs no treatment/placebo

• Systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 33 participants
  Very low

Antibiotics vs no treatment/placebo

The review found no eligible studies for this question.

• Systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antibiotics vs no treatment or placebo on top of topical antibiotics

Systemic antibiotics showed no clear difference in resolution of ear discharge ‐ measured at 1 to 2 weeks compared with no treatment or placebo on top of topical antibiotics (low certainty).

• Systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
  RR 1.02 [0.93, 1.12]
  5 studies · 390 participants
  Low

Antibiotics vs no treatment or placebo on top of topical antibiotics

The review found no eligible studies for this question.

• Systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antibiotics (systemic) vs No antibiotics, placebo, or a different type of antibiotic

The review found no eligible studies for this question.

• Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth 2013 · Cochrane All outcomes

  Minimum 12 months follow-up
  Types of antibiotics: the effect of using no antibiotics, a placebo or different types of antibiotics. Main results: No randomised or quasi-randomised controlled trials were found; no study was included in this review.
  0 studies
  No studies found

Preoperative antibiotics vs placebo or no antibiotic

Preoperative antibiotics probably leads to lower wound infections Proportion of wound infections compared with placebo or no antibiotic (moderate certainty).

• Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery 2019 · Cochrane Headline outcomes only
  RR 0.67 [0.53, 0.85]
  10 studies · 2823 participants
  Moderate

Preoperative antibiotics vs placebo or no antibiotic

• Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery 2019 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 2818 participants
  Very low

Preoperative antibiotics vs placebo or no antibiotic

• Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 1450 participants
  Low

Preoperative antibiotics vs placebo or no antibiotic

• Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 784 participants
  Low

Preoperative antibiotics vs placebo or no antibiotic

• Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 510 participants
  Low

Prophylactic antibiotics vs placebo

Prophylactic antibiotics showed no clear difference in preterm prelabour rupture of membranes compared with placebo (low certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.31 [0.06, 1.49]
  1 study · 229 participants
  Low

Prophylactic antibiotics vs placebo

Prophylactic antibiotics may leads to lower prelabour rupture of membranes compared with placebo (low certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.34 [0.15, 0.78]
  1 study · 229 participants
  Low

Prophylactic antibiotics vs placebo

Prophylactic antibiotics showed no clear difference in preterm delivery compared with placebo (high certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.88 [0.72, 1.09]
  6 studies · 3663 participants
  High

Prophylactic antibiotics vs placebo

It is very uncertain whether prophylactic antibiotics changes chorioamnionitis compared with placebo (very low certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.62 [0.1, 3.62]
  1 study · 229 participants
  Very low

Prophylactic antibiotics vs placebo

Prophylactic antibiotics probably leads to lower puerperal sepsis/postpartum endometritis compared with placebo (moderate certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.53 [0.35, 0.82]
  3 studies · 627 participants
  Moderate

Prophylactic antibiotics vs placebo

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported