Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 4 · 66.7%Low 0 · 0%Moderate 0 · 0%High 1 · 16.7%

Antibiotics vs no treatment

Failure to induce clinical remission at end of study · of active and inactive people with ulcerative colitis

It is very uncertain whether antibiotics changes failure to induce clinical remission at end of study compared with no treatment (very low certainty).

1 finding from 1 review

Antibiotics for the induction and maintenance of remission in ulcerative colitis 2022 · Cochrane Headline outcomes only
RR 0.56 [0.29, 1.07]
1 study · 20 participants
Very low

Antibiotics vs placebo

Failure to induce clinical remission at end of study · people with active UC

Antibiotics showed no clear difference in failure to induce clinical remission at end of study compared with placebo (high certainty).

1 finding from 1 review

Antibiotics for the induction and maintenance of remission in ulcerative colitis 2022 · Cochrane Headline outcomes only
RR 0.88 [0.74, 1.06]
7 studies · 608 participants
High

Antibiotics vs probiotic

Failure to induce clinical remission at end of study · people with active UC

It is very uncertain whether antibiotics changes failure to induce clinical remission at end of study compared with probiotics (very low certainty).

1 finding from 1 review

Antibiotics for the induction and maintenance of remission in ulcerative colitis 2022 · Cochrane Headline outcomes only
RR 0.47 [0.23, 0.94]
1 study · 50 participants
Very low

Antibiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Failure to induce clinical remission at end of study · people with active UC

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics for the induction and maintenance of remission in ulcerative colitis 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antibiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Failure to maintain clinical remission at end of study · Patients with quiescent ulcerative colitis

It is very uncertain whether antibiotics changes failure to maintain clinical remission at end of study compared with 5‐ASA (very low certainty).

1 finding from 1 review

Antibiotics for the induction and maintenance of remission in ulcerative colitis 2022 · Cochrane Headline outcomes only
RR 0.71 [0.47, 1.06]
1 study · 40 participants
Very low

Antibiotics plus probiotics vs placebo or no intervention

Failure to induce clinical remission at end of study · people with active UC

It is very uncertain whether antibiotics plus probiotics changes failure to induce clinical remission at end of study compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Antibiotics for the induction and maintenance of remission in ulcerative colitis 2022 · Cochrane Headline outcomes only
RR 0.68 [0.39, 1.19]
2 studies · 98 participants
Very low