Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

888 questions · 936 findings · 109 reviews

No studies found 196 · 20.9%GRADE not reported 88 · 9.4%Very low 226 · 24.1%Low 217 · 23.2%Moderate 152 · 16.2%High 57 · 6.1%

Antibiotics vs placebo or no antibiotic

Definite early‐onset neonatal sepsis ‐ Late induction of labour · pregnant women with prelabour rupture of membranes at or near term

It is very uncertain whether any antibiotic changes definite early‐onset neonatal sepsis ‐ Late induction of labour compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no antibiotic

Maternal infectious morbidity (chorioamnionitis and/or endometritis) ‐ Early induction of labour · pregnant women with prelabour rupture of membranes at or near term

Any antibiotic showed no clear difference in maternal infectious morbidity (chorioamnionitis and/or endometritis)… compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no antibiotic

Maternal infectious morbidity (chorioamnionitis and/or endometritis) ‐ Late induction of labour · pregnant women with prelabour rupture of membranes at or near term

It is very uncertain whether any antibiotic changes maternal infectious morbidity (chorioamnionitis and/or endometritis)… compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Delayed antibiotics vs no antibiotics

Patient satisfaction: delayed (prescription collection) versus no antibiotics · respiratory infections

Summary of findings table ‐ Delayed antibiotics probably leads to higher patient satisfaction: delayed (prescription collection) versus no… compared with no antibiotics (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Delayed antibiotics vs immediate antibiotics

Antibiotic use: delayed (all strategies) versus immediate antibiotics · respiratory infections

Summary of findings table ‐ Delayed antibiotics probably leads to lower antibiotic use: delayed (all strategies) versus immediate antibiotics compared with immediate antibiotics (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Delayed antibiotics vs immediate antibiotics

Patient satisfaction: delayed (all strategies) versus immediate antibiotics · respiratory infections

Summary of findings table ‐ Delayed antibiotics showed no clear difference in patient satisfaction: delayed (all strategies) versus immediate… compared with immediate antibiotics (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Delayed antibiotics vs immediate antibiotics

Reconsultations · respiratory infections

Summary of findings table ‐ Delayed antibiotics showed no clear difference in reconsultation rate: delayed (all strategies) versus immediate… compared with immediate antibiotics (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Delayed antibiotics vs no antibiotics

Antibiotic use: delayed (all strategies) versus no antibiotics · respiratory infections

Summary of findings table ‐ Delayed antibiotics probably leads to higher antibiotic use: delayed (all strategies) versus no antibiotics compared with no antibiotics (moderate certainty).

1 finding from 1 review