Febrile patients and episodes · patients with afebrile neutropenia induced by chemotherapy
Summary of findings: antibiotics probably leads to lower febrile patients and episodes compared with placebo or no intervention (moderate certainty).
1 finding from 1 review
Bacteraemia · patients with afebrile neutropenia induced by chemotherapy
Summary of findings: antibiotics leads to lower bacteraemia compared with placebo or no intervention (high certainty).
1 finding from 1 review
Exacerbation frequency · people with bronchiectasis
14 days on/off antibiotic regimen probably leads to lower exacerbation frequency compared with 14 days on/off placebo regimen (moderate certainty).
2 findings from 1 review
RR 0.75 [0.61, 0.93]
Studies not reported
Moderate
no estimate extracted
Studies not reported
Moderate
Serious adverse events · people with bronchiectasis
28 days on/off antibiotic regimen showed no clear difference in serious adverse events compared with 28 days on/off placebo regimen (low certainty).
1 finding from 1 review
OR 1 [0.68, 1.46]
Studies not reported
Low
Pulmonary exacerbations: number of hospitalisations due to respiratory exacerbations · people with bronchiectasis
28 days on/off antibiotic regimen showed no clear difference in hospitalisation for pulmonary exacerbations compared with 28 days on/off placebo regimen (high certainty).
1 finding from 1 review
OR 0.79 [0.49, 1.29]
Studies not reported
High
Health‐related quality of life · people with bronchiectasis
2 findings from 1 review
no estimate extracted
Studies not reported
Moderate
no estimate extracted
Studies not reported
Low
Serious adverse events · people with bronchiectasis
14 days on/off antibiotic regimen showed no clear difference in serious adverse events compared with 14 days on/off placebo regimen (high certainty).
1 finding from 1 review
OR 0.92 [0.63, 1.33]
Studies not reported
High
Frequency of hospital admissions for pulmonary exacerbations ‐ not measured · people with bronchiectasis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Health‐related quality of life · people with bronchiectasis
2 findings from 1 review
no estimate extracted
Studies not reported
High
no estimate extracted
Studies not reported
Moderate
Exacerbation frequency · people with bronchiectasis
28 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off placebo regimen (high certainty).
2 findings from 1 review
RR 0.92 [0.82, 1.02]
Studies not reported
High
no estimate extracted
Studies not reported
Low
Resolution of ear discharge ‐ measured at 1 to 2 weeks · chronic suppurative otitis media
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Resolution of ear discharge ‐ measured after 4 weeks · chronic suppurative otitis media
1 finding from 1 review
Health‐related quality of life · chronic suppurative otitis media
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Ear pain (otalgia) or discomfort or local irritation · chronic suppurative otitis media
1 finding from 1 review
Hearing · chronic suppurative otitis media
1 finding from 1 review
Serious complications (including intracranial complications, extracranial complications and death) · chronic suppurative otitis media
1 finding from 1 review
Suspected ototoxicity · chronic suppurative otitis media
1 finding from 1 review
Resolution of VUR · primary VUR
Antibiotic prophylaxis showed no clear difference in resolution of VUR after 1 to 2 years: unit of analysis (children) compared with surveillance or no treatment (low certainty).
1 finding from 1 review
Adverse events · primary VUR
Antibiotic prophylaxis showed no clear difference in adverse events compared with surveillance or no treatment (moderate certainty).
1 finding from 1 review
Microbial resistance to prophylactic drug: unit of analysis (UTI) · primary VUR
Antibiotic prophylaxis probably leads to higher microbial resistance to prophylactic drug: unit of analysis (UTI) compared with surveillance or no treatment (moderate certainty).
1 finding from 1 review