What do systematic reviews say?

Systemic antibiotics alone vs systematic antibiotics plus antibiotic lock solution

It is very uncertain whether systemic antibiotics alone changes cure: successful eradication of the infection compared with systematic antibiotics plus antibiotic lock solution (very low certainty).

• Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis 2022 · Cochrane Headline outcomes only
  RR 1.61 [1.16, 2.23]
  1 study · 64 participants
  Very low

Systemic antibiotics alone vs systematic antibiotics plus antibiotic lock solution

The review found no eligible studies for this question.

• Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Treatment with antibiotics vs No antibiotics, placebo, or different types of antibiotics

The review found no eligible studies for this question.

• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Summary of findings table ‐ Delayed antibiotics vs immediate antibiotics

• Immediate versus delayed versus no antibiotics for respiratory infections 2023 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 2748 participants
  Moderate

Summary of findings table ‐ Delayed antibiotics vs immediate antibiotics

• Immediate versus delayed versus no antibiotics for respiratory infections 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1077 participants
  Moderate

Summary of findings table ‐ Delayed antibiotics vs no antibiotics

• Immediate versus delayed versus no antibiotics for respiratory infections 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1685 participants
  Moderate

Summary of findings table ‐ Delayed antibiotics vs no antibiotics

• Immediate versus delayed versus no antibiotics for respiratory infections 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 585 participants
  Moderate

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in prosthesis failure compared with no antibiotics or placebo; GRADE not reported.

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  3 to 5 months
  RR 0.44 [0.19, 1.00]
  5 studies · 1107 participants
  GRADE not reported

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in postoperative infection compared with no antibiotics or placebo; GRADE not reported.

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  3 to 5 months
  RR 0.69 [0.36, 1.35]
  6 studies · 1162 participants
  GRADE not reported

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) probably leads to lower implant failure compared with no antibiotics or placebo (moderate certainty).

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  4 months
  RR 0.33 [0.16, 0.67]
  6 studies · 1162 participants
  Moderate

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in adverse events compared with no antibiotics or placebo; GRADE not reported.

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  3 to 5 months
  RR 1.0 [0.06, 15.85]
  6 studies · 1162 participants
  GRADE not reported

Antibiotics on removal of central venous catheter vs no antibiotics

Antibiotics on removal of central venous catheter showed no clear difference in late‐onset blood steam infection compared with no antibiotics (low certainty).

• Antibiotics at the time of removal of central venous catheter to reduce morbidity and mortality in newborn infants 2018 · Cochrane Headline outcomes only
  RR 0.09 [0.01, 1.6]
  1 study · 88 participants
  Low

Antibiotics on removal of central venous catheter vs no antibiotics

• Antibiotics at the time of removal of central venous catheter to reduce morbidity and mortality in newborn infants 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 88 participants
  Low

Antibiotics on removal of central venous catheter vs no antibiotics

• Antibiotics at the time of removal of central venous catheter to reduce morbidity and mortality in newborn infants 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 88 participants
  Low

Antibiotics on removal of central venous catheter vs no antibiotics

• Antibiotics at the time of removal of central venous catheter to reduce morbidity and mortality in newborn infants 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 88 participants
  Low

Antibiotics on removal of central venous catheter vs no antibiotics

Antibiotics on removal of central venous catheter showed no clear difference in central line‐associated blood stream infection compared with no antibiotics (low certainty).

• Antibiotics at the time of removal of central venous catheter to reduce morbidity and mortality in newborn infants 2018 · Cochrane Headline outcomes only
  RR 0.09 [0.01, 1.6]
  1 study · 88 participants
  Low

Antibiotics (short duration) vs antibiotics (long duration) postpartum

• Antibiotic regimens for management of intra‐amniotic infection 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Antibiotics (short duration) vs antibiotics (long duration) postpartum

Antibiotics (short duration) showed no clear difference in wound infection compared with antibiotics (long duration) postpartum (low certainty).

• Antibiotic regimens for management of intra‐amniotic infection 2014 · Cochrane Headline outcomes only
  RR 1.87 [0.17, 20.37]
  1 study · 292 participants
  Low

Antibiotics (short duration) vs antibiotics (long duration) postpartum

• Antibiotic regimens for management of intra‐amniotic infection 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 292 participants
  Moderate

Antibiotics (short duration) vs antibiotics (long duration) postpartum

• Antibiotic regimens for management of intra‐amniotic infection 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported