Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

888 questions · 936 findings · 109 reviews

No studies found 196 · 20.9%GRADE not reported 88 · 9.4%Very low 226 · 24.1%Low 217 · 23.2%Moderate 152 · 16.2%High 57 · 6.1%

Antibiotics vs placebo or usual care

Serious adverse events Duration 3 days to 3 weeks · acute asthma exacerbation

Antibiotics showed no clear difference in serious adverse events Duration 3 days to 3 weeks compared with placebo or usual care (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Children not cured or substantially improved at · prolonged wet cough in children

Antibiotics probably leads to lower children not cured or substantially improved at compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Children with progression of the disease resulting in additional medical therapy (complications) (measured as proportion of participants) · prolonged wet cough in children

Antibiotics probably leads to lower children with progression of the disease resulting in additional… compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Cure in adults with clinically diagnosed acute rhinosinusitis · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to higher cure in adults with clinically diagnosed acute rhinosinusitis compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Cure in adults with acute rhinosinusitis confirmed by radiography1 · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics probably leads to higher cure in adults with acute rhinosinusitis confirmed by radiography1 compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Cure in adults with acute rhinosinusitis confirmed by computed tomography1,4 · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics probably leads to higher cure in adults with acute rhinosinusitis confirmed by computed… compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Resolution of purulent secretion · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to higher severity or duration of different clinical symptoms: resolution of… compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Side effects – overall · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to higher side effects: total compared with placebo (high certainty).

1 finding from 1 review