Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

56 questions · 56 findings · 21 reviews

No studies found 8 · 14.3%GRADE not reported 9 · 16.1%Very low 17 · 30.4%Low 15 · 26.8%Moderate 5 · 8.9%High 2 · 3.6%

Antibiotics vs placebo

Serious adverse events WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo or usual care

Serious adverse events Duration 3 days to 3 weeks · acute asthma exacerbation

Antibiotics showed no clear difference in serious adverse events Duration 3 days to 3 weeks compared with placebo or usual care (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Discontinuation of medication due to adverse events · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in adverse events causing study drug discontinuation compared with placebo (low certainty).

1 finding from 1 review

Oral antibiotics vs placebo

Adverse events at 1 month · adult participants with chronic blepharitis

It is very uncertain whether oral antibiotics changes adverse events at 1 month compared with placebo (very low certainty).

1 finding from 1 review

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Adverse events · Adults undergoing dental implant placement

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in adverse events compared with no antibiotics or placebo; GRADE not reported.

1 finding from 1 review