Response rates Number of participants showing a reduction of at least 50% on the Hamilton Depression Rating Scale for Depression, the Montgomery‐Asberg Depression Rating Scale or any other depression scale · adults with Major Depressive Disorder
Amitriptyline probably leads to higher response to treatment At least 50% reduction of a depression scale… compared with placebo (moderate certainty).
1 finding from 1 review
Death due to suicide · adults with Major Depressive Disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · adults with Major Depressive Disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability of treatment Drop‐out for any reason · adults with Major Depressive Disorder
It is very uncertain whether amitriptyline changes acceptability of treatment Drop‐out for any reason compared with placebo (very low certainty).
1 finding from 1 review
Adverse effects (drop‐outs due to adverse effects4) · adults with Major Depressive Disorder
Amitriptyline probably leads to higher overall tolerability Drop‐out due to adverse events compared with placebo (moderate certainty).
1 finding from 1 review
Seizure frequency · people with epilepsy and depression
1 finding from 1 review
Treatment withdrawal · people with epilepsy and depression
1 finding from 1 review
Cognitive function · people with epilepsy and depression
1 finding from 1 review
Quality of life · people with epilepsy and depression
1 finding from 1 review
Adverse effects · people with epilepsy and depression
1 finding from 1 review
> 50% reduction in depressive symptoms · people with epilepsy and depression
Amitriptyline showed no clear difference in > 50% reduction in depressive symptoms compared with nomifensine (low certainty).
1 finding from 1 review
Mean depression scores · people with epilepsy and depression
1 finding from 1 review
Participant‐reported pain relief of 30% or greater · children and adolescents with chronic non‐cancer pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · children and adolescents with chronic non‐cancer pain
1 finding from 1 review
Serious adverse events · children and adolescents with chronic non‐cancer pain
1 finding from 1 review
Withdrawals due to adverse events · children and adolescents with chronic non‐cancer pain
1 finding from 1 review
Participant‐reported pain relief of 50% or greater · children and adolescents with chronic non‐cancer pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Patient Global Impression of Change much or very much improved · children and adolescents with chronic non‐cancer pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · children and adolescents with chronic non‐cancer pain
1 finding from 1 review
Serious adverse events · children and adolescents with chronic non‐cancer pain
1 finding from 1 review