Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

16 questions · 17 findings · 4 reviews

No studies found 9 · 52.9%GRADE not reported 2 · 11.8%Very low 0 · 0%Low 3 · 17.6%Moderate 3 · 17.6%High 0 · 0%

Amantadine vs placebo

Risk for at least one adverse event per patient · patients with the treatment of cocaine dependence

Amantadine showed no clear difference in adverse events as N of participants with at least one adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Amantadine vs placebo

Abstinence · patients with the treatment of cocaine dependence

Amantadine showed no clear difference in abstinence (objective) N of subjects abstinent at the end of the study compared with placebo (low certainty).

2 findings from 1 review

Amantadine vs placebo

Activity limitations ‐ not measured · people with postpolio syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Amantadine vs placebo

Reduction in fatigue · people with fatigue in Guillain‐Barré syndrome

Amantadine showed no clear difference in reduction in fatigue of at least 1‐point on the Fatigue Severity… compared with placebo (low certainty).

1 finding from 1 review

Amantadine vs placebo

Health related quality of life after 12 or more weeks or more after commencement of intervention (not reported) · people with fatigue in Guillain‐Barré syndrome

The review found no eligible studies for this question.

1 finding from 1 review