Death ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydrammine led to lower death ‐ not reported compared with placebo (Unit of randomisation: transfusion); GRADE not reported.
1 finding from 1 review
Postoperative pain (dichotomous measure: parent report of presence of pain-related behaviours) · Children and adolescents having dental treatment under local anaesthetic (restorative and extraction treatments)
Preoperative paracetamol (acetaminophen) showed no clear difference in postoperative pain (dichotomous measure: parent report of presence… compared with placebo (low certainty).
1 finding from 1 review
Adverse events · Children and adolescents having dental treatment under local anaesthetic (restorative and extraction treatments)
1 finding from 1 review
Number of participants reporting an adverse event · patients with osteoarthritis
Tramadol in combination with acetaminophen probably leads to higher number of participants experiencing any adverse event compared with placebo (moderate certainty).
1 finding from 1 review
Withdrawals due to adverse events · patients with osteoarthritis
Tramadol in combination with acetaminophen may leads to higher number of participants who withdrew due to adverse events compared with placebo (low certainty).
1 finding from 1 review
Number of participants experiencing any serious adverse events · patients with osteoarthritis
1 finding from 1 review
Outcomesa · patients with osteoarthritis
The review found no eligible studies for this question.
1 finding from 1 review
Pain · patients with osteoarthritis
1 finding from 1 review
Physical function · patients with osteoarthritis
1 finding from 1 review
Number of participants reporting an adverse event · patients with osteoarthritis
Tramadol in combination with acetaminophen showed no clear difference in number of participants experiencing any adverse event compared with NSAIDs (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · patients with osteoarthritis
The review found no eligible studies for this question.
1 finding from 1 review
Number of participants experiencing any serious adverse events · patients with osteoarthritis
1 finding from 1 review
Outcomesa · patients with osteoarthritis
The review found no eligible studies for this question.
1 finding from 1 review
Pain · patients with osteoarthritis
1 finding from 1 review
Physical function · patients with osteoarthritis
The review found no eligible studies for this question.
1 finding from 1 review
Number of participants reporting an adverse event · patients with osteoarthritis
The review found no eligible studies for this question.
1 finding from 1 review
Withdrawals due to adverse events · patients with osteoarthritis
The review found no eligible studies for this question.
1 finding from 1 review
Number of participants experiencing any serious adverse events · patients with osteoarthritis
The review found no eligible studies for this question.
1 finding from 1 review
Outcomesa · patients with osteoarthritis
The review found no eligible studies for this question.
1 finding from 1 review
Pain · patients with osteoarthritis
1 finding from 1 review