Findings

What do systematic reviews say?

14 questions · 14 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 6 · 42.9%Very low 2 · 14.3%Low 4 · 28.6%Moderate 2 · 14.3%High 0 · 0%

ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY

Relapse · patients with schizophrenia

ANY INTERMITTENT DRUG TECHNIQUE probably leads to higher relapse: long term (+ 26 weeks) as defined in each study compared with MAINTENANCE THERAPY (moderate certainty).

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
RR 2.46 [1.7, 3.54]
7 studies · 436 participants
Moderate

ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY

Hospital admissions · patients with schizophrenia

ANY INTERMITTENT DRUG TECHNIQUE probably leads to higher hospitalisation: long term (+ 26 weeks) as defined in each study compared with MAINTENANCE THERAPY (moderate certainty).

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
RR 1.65 [1.33, 2.06]
5 studies · 626 participants
Moderate

ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY

Global state: average score: long term (+ 26 weeks) Global Assessment Scale (GAS). Scale from: 0 to 100. · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 133 participants
Low

ANY INTERMITTENT DRUG TECHNIQUE vs placebo

Relapse · patients with schizophrenia

It is very uncertain whether ANY INTERMITTENT DRUG TECHNIQUE changes relapse: medium term (13‐25 weeks) as defined in each study compared with PLACEBO (very low certainty).

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.36 [0.23, 0.57]
2 studies · 288 participants
Very low

ANY INTERMITTENT DRUG TECHNIQUE vs placebo

Hospital admissions · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

ANY INTERMITTENT DRUG TECHNIQUE vs placebo

Global state Global Assessment Scale (GAS) · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

ANY INTERMITTENT DRUG TECHNIQUE vs placebo

Mental state · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY

Mental state · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 77 participants
Low

ANY INTERMITTENT DRUG TECHNIQUE vs placebo

Adverse effects: tardive dyskinesia: medium term (13‐25 weeks) as defined in each study · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

ANY INTERMITTENT DRUG TECHNIQUE vs placebo

Cost‐effectiveness · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

ANY INTERMITTENT DRUG TECHNIQUE vs placebo

Leaving the study early/ loss to · patients with schizophrenia

It is very uncertain whether ANY INTERMITTENT DRUG TECHNIQUE changes leaving the study early/ loss to compared with PLACEBO (very low certainty).

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
RR 1.97 [1.28, 3.01]
2 studies · 90 participants
Very low

ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY

Adverse effects: tardive dyskinesia: long term (+ 26 weeks) as defined in each study · patients with schizophrenia

ANY INTERMITTENT DRUG TECHNIQUE showed no clear difference in adverse effects: tardive dyskinesia: by long term (+26 weeks) as… compared with MAINTENANCE THERAPY (low certainty).

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
RR 1.15 [0.58, 2.3]
4 studies · 165 participants
Low

ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY

Cost‐effectiveness · patients with schizophrenia

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY

Leaving the study early/ loss to · patients with schizophrenia

ANY INTERMITTENT DRUG TECHNIQUE may leads to higher leaving the study early/ loss to compared with MAINTENANCE THERAPY (low certainty).

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
RR 1.63 [1.23, 2.15]
10 studies · 996 participants
Low