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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

361 questions in 74 reviews · Pain, Palliative and Supportive Care

current versions
No studies 361 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Summary of findings table ‐ Kappa‐opioid agonists vs placebo
Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Kappa‐opioid agonists vs placebo
Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Kappa‐opioid agonists vs placebo
Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Ondansetron vs placebo
Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Ondansetron vs placebo
Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Ondansetron vs placebo
Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ GABA‐analogues vs placebo
Quality of life ‐ not measured · health problem or population
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Montelukast vs placebo
Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Montelukast vs placebo
Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Montelukast vs placebo
depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Montelukast vs placebo
Risk for at least one adverse event per participant ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo
Quality of life ‐ not measured · chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo
Patient satisfaction ‐ not measured · chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo
Depression ‐ not measured · chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ GABA‐analogues vs placebo
Patient satisfaction ‐ not measured · health problem or population
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo
Adverse events ‐ not measured · chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Zinc sulphate vs placebo
Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Zinc sulphate vs placebo
Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Zinc sulphate vs placebo
Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Cromolyn sodium vs placebo
Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Cromolyn sodium vs placebo
Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Cromolyn sodium vs placebo
Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ GABA‐analogues vs placebo
Depression ‐ not reported · health problem or population
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Topical capsaicin vs placebo
Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Topical capsaicin vs placebo
Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Topical capsaicin vs placebo
Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Naltrexone vs placebo
Quality of life ‐ not measured · patients with cholestatic pruritus (CP)
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Naltrexone vs placebo
Patient satisfaction ‐ not measured · patients with cholestatic pruritus (CP)
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Naltrexone vs placebo
Depression ‐ not measured · patients with cholestatic pruritus (CP)
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Rifampin/rifampicin vs placebo
Quality of life ‐ not measured · patients with cholestatic pruritus (CP)
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Rifampin/rifampicin vs placebo
Patient satisfaction ‐ not measured · patients with cholestatic pruritus (CP)
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Rifampin/rifampicin vs placebo
Depression ‐ not measured · patients with cholestatic pruritus (CP)
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Flumecinol vs placebo
Patient satisfaction ‐ not measured · patients with cholestatic pruritus (CP)
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Flumecinol vs placebo
Depression ‐ not measured · patients with cholestatic pruritus (CP)
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Flumecinol vs placebo
Risk for at least one adverse event per patient ‐ not measured · patients with cholestatic pruritus (CP)
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Gabapentin vs pregabalin
Quality of life ‐ not reported · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Gabapentin vs pregabalin
Patient satisfaction ‐ not reported · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Gabapentin vs pregabalin
Depression ‐ not reported · patients with chronic kidney disease (CKD) pruritus
Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane
no estimate extractedNRNo studies
Ibuprofen vs placebo
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, less than 2 hours postintervention · children aged 17 years or younger treated for acute postoperative or postprocedural pain
Ibuprofen for acute postoperative pain in children (2024) · Cochrane
no estimate extractedNRNo studies
Ibuprofen vs paracetamol
Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children aged 17 years or younger treated for acute postoperative or postprocedural pain
Ibuprofen for acute postoperative pain in children (2024) · Cochrane
no estimate extractedNRNo studies
Ibuprofen vs morphine
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, less than 2 hours postintervention · children aged 17 years or younger treated for acute postoperative or postprocedural pain
Ibuprofen for acute postoperative pain in children (2024) · Cochrane
no estimate extractedNRNo studies
Ibuprofen vs morphine
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, 2 hours to less than 24 hours postintervention · children aged 17 years or younger treated for acute postoperative or postprocedural pain
Ibuprofen for acute postoperative pain in children (2024) · Cochrane
no estimate extractedNRNo studies
Ibuprofen vs morphine
Pain intensity – as reported by the child, less than 2 hours postintervention · children aged 17 years or younger treated for acute postoperative or postprocedural pain
Ibuprofen for acute postoperative pain in children (2024) · Cochrane
no estimate extractedNRNo studies
Ibuprofen vs morphine
Pain intensity – as reported by the child, 2 hours to less than 24 hours postintervention · children aged 17 years or younger treated for acute postoperative or postprocedural pain
Ibuprofen for acute postoperative pain in children (2024) · Cochrane
no estimate extractedNRNo studies
Ibuprofen vs morphine
Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children aged 17 years or younger treated for acute postoperative or postprocedural pain
Ibuprofen for acute postoperative pain in children (2024) · Cochrane
no estimate extractedNRNo studies
Ibuprofen vs ketorolac
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, less than 2 hours postintervention · children aged 17 years or younger treated for acute postoperative or postprocedural pain
Ibuprofen for acute postoperative pain in children (2024) · Cochrane
no estimate extractedNRNo studies
Ibuprofen vs placebo
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, 2 hours to less than 24 hours postintervention · children aged 17 years or younger treated for acute postoperative or postprocedural pain
Ibuprofen for acute postoperative pain in children (2024) · Cochrane
no estimate extractedNRNo studies
Ibuprofen vs ketorolac
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, 2 hours to less than 24 hours postintervention · children aged 17 years or younger treated for acute postoperative or postprocedural pain
Ibuprofen for acute postoperative pain in children (2024) · Cochrane
no estimate extractedNRNo studies
Ibuprofen vs ketorolac
Pain intensity – as reported by the child, less than 2 hours postintervention · children aged 17 years or younger treated for acute postoperative or postprocedural pain
Ibuprofen for acute postoperative pain in children (2024) · Cochrane
no estimate extractedNRNo studies
Ibuprofen vs ketorolac
Pain intensity – as reported by the child, 2 hours to less than 24 hours postintervention · children aged 17 years or younger treated for acute postoperative or postprocedural pain
Ibuprofen for acute postoperative pain in children (2024) · Cochrane
no estimate extractedNRNo studies